Comparative QSAR and the radical toxicity of various functional groups

被引：84

作者：

Selassie, CD ^{[1
]}

Garg, R ^{[1
]}

Kapur, S ^{[1
]}

Kurup, A ^{[1
]}

Verma, RP ^{[1
]}

Mekapati, SB ^{[1
]}

Hansch, C ^{[1
]}

机构：

[1] Pomona Coll, Dept Chem, Claremont, CA 91711 USA

来源：

CHEMICAL REVIEWS | 2002年 / 102卷 / 07期

关键词：

D O I：

10.1021/cr940024m

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An review is given of the important contributions of physichochemical descriptors that are used to characterize chemical reactivity as well as biological activity. The chemical reactivity of various functional entities such as the nitro, amino, olefinic, hydroxy, and carboxaldehyde groups are examined. These reactivities are then compared to their biological activities versus isolated receptors in cellular systems or in vivo.

引用

收藏

页码：2585 / 2605

页数：21

相关论文

共 160 条

[1] KINETICS AND MECHANISM OF THE OXIDATION OF ORGANIC SULFIDES BY N-CHLOROACETAMIDE [J].

AGARWAL, A ;

BHATT, P ;

BANERJI, KK .

JOURNAL OF PHYSICAL ORGANIC CHEMISTRY, 1990, 3 (03) :174-180

[2] Phenyl β-methoxyacrylates:: A new antimalarial pharmacophore [J].

Alzeer, J ;

Chollet, J ;

Heinze-Krauss, I ;

Hubschwerlen, C ;

Matile, H ;

Ridley, RG .

JOURNAL OF MEDICINAL CHEMISTRY, 2000, 43 (04) :560-568

[3]

ASAKAWA E, 1994, INT J CANCER, V56, P146

[4] KINETICS AND MECHANISM OF OXIDATION OF BENZYL ALCOHOL TO BENZALDEHYDE BY BROMINE [J].

AUKETT, P ;

BARKER, IRL .

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 2, 1972, (05) :568-&

[5] RELATIVE RATES FOR THE ADDITION-REACTIONS OF THE MALONYL RADICAL TO SUBSTITUTED STYRENES INDUCED BY CERIUM(IV) AMMONIUM-NITRATE AND TRIBUTYLTIN HYDRIDE - A COMPARISON [J].

BACIOCCHI, E ;

GIESE, B ;

FARSHCHI, H ;

RUZZICONI, R .

JOURNAL OF ORGANIC CHEMISTRY, 1990, 55 (22) :5688-5691

[6] KINETICS AND MECHANISM OF THE OXIDATION OF SUBSTITUTED BENZYLAMINES BY N-CHLOROSUCCINIMIDE [J].

BANERJI, KK .

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 2, 1988, (06) :1015-1019

[7] MECHANISTIC STUDY OF THE OXIDATION OF SUBSTITUTED BENZYLAMINES BY N-BROMOACETAMIDE [J].

BANERJI, KK .

BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, 1988, 61 (10) :3717-3722

[8] KINETICS AND MECHANISM OF OXIDATION OF SUBSTITUTED BENZYL ALCOHOLS BY CHLORAMINE-T IN ACID-SOLUTION [J].

BANERJI, KK .

BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, 1977, 50 (06) :1616-1618

[9]

BASAK SC, 1983, ARZNEIMITTEL-FORSCH, V33-1, P501

[10] A CRITICAL-REVIEW OF THE LITERATURE ON NITROBENZENE TOXICITY [J].

BEAUCHAMP, RO ;

IRONS, RD ;

RICKERT, DE ;

COUCH, DB ;

HAMM, TE .

CRC CRITICAL REVIEWS IN TOXICOLOGY, 1982, 11 (01) :33-84

← 1 2 3 4 5 6 7 8 9 10 →