Polyphenol rich extracts of finger millet and kodo millet ameliorate high fat diet-induced metabolic alterations

被引:1
作者
Khare, Pragyanshu [1 ]
Maurya, Ruchika [1 ,2 ]
Bhatia, Ruchika [1 ]
Mangal, Priyanka [3 ]
Singh, Jagdeep [1 ]
Podili, Koteswaraiah [4 ]
Bishnoi, Mahendra [1 ]
Kondepudi, Kanthi Kiran [1 ,2 ]
机构
[1] Natl Agrifood Biotechnol Inst NABI, Ctr Excellence Funct Foods, Hlth Gut Res Grp, Sect 81, Sas Nagar 110306, Punjab, India
[2] Reg Ctr Biotechnol, Faridabad 121001, Haryana, India
[3] Natl Inst Pharmaceut Educ & Res NIPER, Sas Nagar 160062, Punjab, India
[4] Vellore Inst Technol, Sch Biosci & Technol, Vellore 632011, Tamil Nadu, India
关键词
ELEUSINE-CORACANA L; OXIDATIVE STRESS; ANTIOXIDANT ACTIVITIES; OBESITY; INFLAMMATION; DERANGEMENTS; MANAGEMENT; FRACTIONS; PROFILE; MICE;
D O I
10.1039/d0fo01643h
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Finger millet (FM) and kodo millet (KM) are known for their multiple health benefits. Several studies have indicated the antioxidant and hypoglycemic potential of polyphenol rich extracts (PREs) from them. However, the protective roles of PREs from these millets in overcoming high-fat diet (HFD)-induced obesity have not yet been investigated. This study aimed to identify the polyphenols in FM-PREs and KM-PREs using HPLC-DAD/ESI-MS, and to evaluate the role of PREs in mitigating lipopolysaccharide induced inflammation in murine macrophage cells and in the reduction of HFD-induced metabolic complications using male Swiss albino mice. The results suggested that KM-PRE had higher polyphenol content than FM-PRE, of which taxifolin (98%) and catechin (86.6%) were the major fractions respectively. FM-PRE and KM-PRE prevented obesity, however, KM-PRE was more profound in preventing weight gain, adipose tissue hypertrophy, hepatic steatosis, and systemic inflammation than FM-PRE. This study suggests that FM-PRE and KM-PRE could be exploited for developing functional foods or nutraceuticals against obesity and comorbidities.
引用
收藏
页码:9833 / 9847
页数:15
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