A low-fat vegan diet improves glycemic control and cardiovascular risk factors in a randomized clinical trial in individuals with type 2 diabetes

被引:287
作者
Barnard, Neal D.
Cohen, Joshua
Jenkins, David J. A.
Turner-McGrievy, Gabrielle
Gloede, Lise
Jaster, Brent
Seidl, Kim
Green, Amber A.
Talpers, Stanley
机构
[1] George Washington Univ, Sch Med, Dept Med, Washington, DC USA
[2] Phys Committ Responsible Med, Washington, DC USA
[3] Univ Toronto, Fac Med, Dept Nutr Sci, Toronto, ON, Canada
[4] St Michaels Hosp, Clin Nutr & Risk Factor Modificat Ctr, Toronto, ON M5B 1W8, Canada
[5] Univ N Carolina, Sch Publ Hlth, Dept Nutr, Chapel Hill, NC USA
关键词
D O I
10.2337/dc06-0606
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
OBJECTIVE - We sought to investigate whether a low-fat vegan diet improves glycemic control and cardiovascular risk factors in individuals with type 2 diabetes, RESEARCH DESIGN AND METHODS - Individuals with type 2 diabetes (n = 99) were randomly assigned to a low-fat vegan diet (n = 49) or a diet following the American Diabetes Association (ADA) guidelines (n = 50). Participants were evaluated at baseline and 22 weeks. RESULTS - Forty-three percent (21 of 49) of the vegan group and 26% (13 of 50) of the ADA group participants reduced diabetes medications. Including all participants, HbA(1c), (A1C) decreased 0.96 percentage points in the vegan group and 0.56 points in the ADA group (P = 0.089). Excluding those who changed medications, A1C fell 1.23 points in the vegan group compared with 0.38 points in the ADA group (P = 0.01). Body weight decreased 6.5 kg in the vegan group and 3.1 kg in the ADA group (P < 0.001). Body weight change correlated with A1C change (r = 0.51, n = 57, P < 0.0001). Among those who did not change lipid-lowering medications, LDL cholesterol fell 21.2% in the vegan group and 10.7% in the ADA group (P = 0.02). After adjustment for baseline values, urinary albumin reductions were greater in the vegan group (15.9 mg/24h) than in the ADA group (10.9 mg/24 h) (P = 0.013). CONCLUSIONS - Both a low-fat vegan diet and a diet based on ADA guidelines improved glycemic and lipid control in type 2 diabetic patients. These improvements were greater with a low-fat vegan diet.
引用
收藏
页码:1777 / 1783
页数:7
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