Serum and salivary interleukin-4 levels in patients with oral lichen planus: A systematic review and meta-analysis

被引：10

作者：

Mozaffari, Hamid Reza ^{[1
,2
]}

Zavattaro, Elisa ^{[3
]}

Saeedi, Mina ^{[4
]}

Lopez-Jornet, Pia ^{[5
]}

Sadeghi, Masoud ^{[2
,4
]}

Safaei, Mohsen ^{[6
]}

Imani, Mohammad Moslem ^{[7
]}

Nourbakhsh, Reza ^{[6
]}

Moradpoor, Hedaiat ^{[8
]}

Golshah, Amin ^{[7
]}

Sharifi, Roohollah ^{[9
]}

机构：

[1] Kermanshah Univ Med Sci, Sch Dent, Dept Oral & Maxillofacial Med, Kermanshah, Iran

[2] Kermanshah Univ Med Sci, Med Biol Res Ctr, Kermanshah, Iran

[3] Univ Eastern Piedmont Amedeo Avogadro, Dept Translat Med, Dermatol Unit, I-28100 Novara, Italy

[4] Kermanshah Univ Med Sci, Students Res Comm, Kermanshah, Iran

[5] Univ Murcia, Hosp Morales Meseguer, Fac Med & Odontol, Clin Odontol Adv Marques Velez S-N, Murcia 30008, Spain

[6] Kermanshah Univ Med Sci, Sch Dent, Oral & Dent Sci Res Lab, Kermanshah, Iran

[7] Kermanshah Univ Med Sci, Sch Dent, Dept Orthodont, Kermanshah, Iran

[8] Kermanshah Univ Med Sci, Sch Dent, Dept Prosthodont, Kermanshah, Iran

[9] Kermanshah Univ Med Sci, Sch Dent, Dept Endodont, Kermanshah, Iran

来源：

ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY | 2019年 / 128卷 / 02期

关键词：

INTERFERON-GAMMA; IFN-GAMMA; EXPRESSION; IL-4; PATHOGENESIS; ASSOCIATION;

D O I：

10.1016/j.oooo.2019.04.003

中图分类号：

R78 [口腔科学];

学科分类号：

1003 ;

摘要：

Objective. Cytokines have an important role in keratinocyte immune damage and can act in the pathogenesis of different cutaneous diseases. Accordingly, in the literature, interleukin 4 (IL-4) concentration has been previously investigated in patients affected by oral lichen planus (OLP). Study design. The present meta-analysis evaluated the serum and salivary levels of IL-4 in connection with several OLP variants. The search was performed from 1995 in Cochrane Library and 1983 in Scopus, PubMed, and Web of Science to September 2018. The quality of the studies included in the meta-analysis was assessed using the Newcastle-Ottawa Scale assessment. The analyses were done by Review Manager 5.3 using mean difference (MD) and 95% confidence intervals (CIs). Results. Out of 108 studies retrieved in the databases, only 10 were included and analyzed in quantitative synthesis. The pooled MD of the serum and salivary IL-4 levels in OLP patients compared with the controls was 6.36 picograms/milliliter (pg/mL) (95% CI: 1.47, 11.24; P = .01) and 2.67 pg/mL (95% CI: 2.66, 2.68; P < .00001), respectively. In addition, the pooled MD of serum and salivary IL-4 level was 1.30 pg/mL (95% CI: -0.35, 2.95; P = .12) and 1.83 pg/mL (95% CI: 0.26, 3.40; P = .02), respectively, in patients with erosive, erythematous, bullous, and ulcerative variants of OLP compared with patients with reticular OLP. Conclusions. This meta-analysis found that OLP patients present elevated serum and salivary IL-4 levels, thus indicating that IL-4 may represent a potential salivary biomarker for the disease. By contrast, clinicians must be aware that even other factors (e.g., secondary infection) may influence its concentration.

引用

页码：123 / 131

页数：9