BRG1 is correlated with poor prognosis in colorectal cancer

被引：31
作者：
Pyo, Jung-Soo [1 ]
Son, Byoung Kwan [2 ]
Oh, Dongwook [2 ]
Kim, Eun Kyung [3 ]
机构：
[1] Eulji Univ, Sch Med, Eulji Univ Hosp, Dept Pathol, Daejeon 35233, South Korea
[2] Eulji Univ, Sch Med, Eulji Hosp, Dept Internal Med, 68 Hangeulbiseok Ro, Seoul 01830, South Korea
[3] Eulji Univ, Sch Med, Eulji Hosp, Dept Pathol, Seoul 01830, South Korea
来源：
HUMAN PATHOLOGY | 2018年 / 73卷
关键词：
Colorectal cancer; Brahma-related gene 1; Prognosis; Immunohistochemistry; Meta-analysis; SWI/SNF COMPLEX; GASTRIC CARCINOMAS; LUNG-CANCER; CELL-LINES; EXPRESSION; CHROMATIN; PROLIFERATION; MUTATIONS; COMPONENT; SURVIVAL;
D O I：
10.1016/j.humpath.2017.12.013
中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
Brahma-related gene 1 (BRG1), a component of the chromatin-remodeling complex, regulates transcription by remodeling the chromatin structure. The present study aimed to elucidate the clinicopathological significance and prognostic role of BRG1 in colorectal cancer (CRC). We investigated the correlation between BRG1 expression and clinicopathological parameters, including prognosis, using immunohistochemistry on 266 archival paraffin-embedded CRC tissues. In addition, to confirm the prognostic role of BRG 1 in malignant tumors, we performed a meta-analysis of 9 eligible studies and the current study. BRG1 was highly expressed in 67.7% of the 266 CRCs analyzed. High BRG 1 expression significantly correlated with poor overall and recurrence-free survival (P < .001 and P < .001, respectively). The high expression of BRG1 also significantly correlated with high expression of SNAI (P < .001) but not E-cadherin (P = .432). However, there was no significant correlation between BRG1 expression and other clinicopathological parameters. The meta-analysis also demonstrated that high BRG1 expression positively correlated with poor overall and recurrence-free survival (hazard ratio 1.572, 95% confidence interval 1.106-2.235 and hazard ratio 2.050, 95% confidence interval 1.610-2.610, respectively). However, subgroup analysis based on tumor type showed that the correlation between BRG1 expression and poor prognosis was only prevalent in CRC and breast cancer. Taken together, the results of this study suggest that high BRG1 expression was associated with high SNAI expression and was significantly correlated with poor prognosis. (C) 2017 Elsevier Inc. All rights reserved.
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页码：66 / 73
页数：8
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