Comparison of noncontingent versus contingent cocaine administration on plasma corticosterone levels in rats

被引：59
作者：
Galici, R
Pechnick, RN
Poland, RE
France, CP
机构：
[1] Louisiana State Univ, Hlth Sci Ctr, Dept Pharmacol & Expt Therapeut, New Orleans, LA 70119 USA
[2] Louisiana State Univ, Hlth Sci Ctr, Neurosci Ctr Excellence, New Orleans, LA 70119 USA
[3] Cedars Sinai Med Ctr, Dept Psychiat, Thalians Mental Hlth Ctr, Los Angeles, CA 90048 USA
来源：
EUROPEAN JOURNAL OF PHARMACOLOGY | 2000年 / 387卷 / 01期
关键词：
cocaine; corticosterone; neuroendocrine; hypothalamo pituitary-adrenal axis; self-administration; stress;
D O I：
10.1016/S0014-2999(99)00780-3
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The purpose of the present study was to compare the effects of contingent and noncontingent cocaine administration on plasma levels of corticosterone in mts. Male rats were trained to self-administer cocaine under a fixed-ratio 5 schedule. The rats were yoked such that the delivery of cocaine (0.25 mg/kg/infusion) to one rat (contingent cocaine) produced the simultaneous noncontingent delivery of the same dose of cocaine (noncontingent cocaine) or saline (noncontingent saline) to other rats. Although saline administration had no effect, plasma corticosterone levels were significantly higher in rat receiving contingent cocaine compared to those receiving noncontingent cocaine. These results demonstrate that the active vs. passive administration of cocaine can differentially affect this neuroendocrine response, (C) 2000 Elsevier Science B.V. All rights reserved.
引用
收藏
页码：59 / 62
页数：4
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