Probing the effect of a 3′-S-phosphorothiolate link on the conformation of a DNA:RNA hybrid;: implications for antisense drug design

被引：17
|
作者：
Beevers, APG
Fettes, KJ
O'Neil, IA
Roberts, SM
Arnold, JRP
Cosstick, R
Fisher, J [1 ]
机构：
[1] Univ Leeds, Dept Chem, Leeds LS2 9JT, W Yorkshire, England
[2] Univ Liverpool, Dept Chem, Liverpool L69 7ZD, Merseyside, England
[3] Univ Bradford, YCR Lab Drug Design, Bradford BD7 1DP, W Yorkshire, England
来源：
CHEMICAL COMMUNICATIONS | 2002年 / 14期
关键词：
D O I：
10.1039/b203582k
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The effects of a single 3'-S-phosphorothiolate link in the DNA strand of a DNA: RNA dodecamer duplex is described; the sulfur induces a conformational shift in the (attached) sugar pucker, as shown by H-1 NMR studies, and increases the thermal stability of the duplex compared to the nonmodified system.
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页码：1458 / 1459
页数：2
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