Humoral intestinal immunity in systemic lupus erythematosus

被引：0

作者：

Elia, C ^{[1
]}

Souza, H ^{[1
]}

Carvalho, AT ^{[1
]}

Madi, K ^{[1
]}

Mello, CA ^{[1
]}

Oliveira, A ^{[1
]}

Cuckier, R ^{[1
]}

Papi, JA ^{[1
]}

机构：

[1] Univ Fed Hosp Rio de Janeiro, Multidisciplinary Lab, Rio De Janeiro, Brazil

来源：

JOURNAL OF CLINICAL GASTROENTEROLOGY | 2000年 / 30卷 / 01期

关键词：

systemic lupus erythematosus; intestinal mucosa; plasma cells; immunoglobulin;

D O I：

10.1097/00004836-200001000-00009

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Forty-five patients with systemic lupus erythematosus (SLE) underwent a cross-sectional study to evaluate intestinal secretory immunity. Peroral jejunal biopsy with histologic and immunohistochemical assessment of the mucosa were carried out in the patients and in 12 healthy volunteers. It was observed that an altered pattern of immunoglobulin-bearing plasma cells distributed in the lamina propria and complementary components were invariably present, mainly in the patients with active disease. The basement membrane of the intestinal crypt epithelium exhibited immunoglobulin and complementary deposits, similar to the lupus band test. None of the immunologic findings correlated with the medical treatment and with the peripheral blood analysis. The local changes in humoral immunity in patients with SLE did not correlate with gastrointestinal symptoms and may reflect the systemic effects of the disease.

引用

页码：52 / 55

页数：4

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