FDG PET/CT and Enhanced CT Imaging of Tumor Heterogeneity in Hepatocellular Carcinoma Imaging-Pathologic Correlation

被引：19

作者：

Dong, Aisheng ^{[1
]}

Yu, Hua ^{[2
]}

Wang, Yang ^{[3
]}

Dong, Hui ^{[3
]}

Zuo, Changjing ^{[1
]}

机构：

[1] Changhai Hosp, Dept Nucl Med, Shanghai 200433, Peoples R China

[2] Eastern Hepatobiliary Surg Hosp, Dept Pathol, Shanghai, Peoples R China

[3] Second Mil Med Univ, Dept Pathol, Changhai Hosp, Shanghai, Peoples R China

来源：

CLINICAL NUCLEAR MEDICINE | 2014年 / 39卷 / 09期

关键词：

tumor heterogeneity; hepatocellular carcinoma; CT; FDG PET; POSITRON-EMISSION-TOMOGRAPHY; GLUCOSE-METABOLISM; EXPRESSION;

D O I：

10.1097/RLU.0b013e3182a75812

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Tumor heterogeneity is used to define the appearance of different histological differentiation within a single neoplasm. We present a case of single hepatocellular carcinoma showing both low and high FDG uptake areas. The low FDG uptake area was corresponding to low-grade HCC, and the high FDG uptake area was corresponding to high-grade HCC. This case indicates that the tumor grades affect intratumoral heterogeneity in FDG distribution. FDG PET/CT can be useful for guiding tissue sampling of the HCC with heterogeneous histological differentiations, and obviating overestimation or underestimation of the proportion of the higher-risk cell population.

引用

页码：808 / 810

页数：3

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