Kidney Transplantation in Children

被引:178
作者
Dharnidharka, Vikas R. [1 ,2 ]
Fiorina, Paolo [3 ,4 ,5 ]
Harmon, William E. [3 ,4 ]
机构
[1] Washington Univ, Div Pediat Nephrol, Sch Med, St Louis, MO 63130 USA
[2] St Louis Childrens Hosp, St Louis, MO 63110 USA
[3] Boston Childrens Hosp, Div Nephrol, Boston, MA 02115 USA
[4] Harvard Univ, Sch Med, Boston, MA 02115 USA
[5] Univ Milan, Osped San Raffaele, Ist Ricovero & Cura Carattere Sci, Div Transplant Med, I-20127 Milan, Italy
关键词
PEDIATRIC RENAL-TRANSPLANTATION; POSTTRANSPLANT LYMPHOPROLIFERATIVE DISORDER; COMPLETE STEROID AVOIDANCE; MESENCHYMAL STEM-CELLS; RANDOMIZED-TRIAL; UNITED-STATES; MYCOPHENOLATE-MOFETIL; ORGAN-TRANSPLANTATION; MESSENGER-RNA; RECIPIENTS;
D O I
10.1056/NEJMra1314376
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Transplantation in children with kidney failure once presented many technical, immunologic, and logistic problems that led to worse patient and allograft survival, as compared with adults. Advances in all these areas and the development of pediatric-trial groups have resulted in dramatic improvements, such that young children now have the best long-term graft survival among all age groups, including adults. Copyright © 2014 Massachusetts Medical Society.
引用
收藏
页码:549 / 558
页数:10
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