New Perspectives on Antimicrobial Agents: Tecovirimat for Treatment of Human Monkeypox Virus

被引：29
作者：
DeLaurentis, Clare E. [1 ]
Kiser, Jennifer [2 ]
Zucker, Jason [1 ]
机构：
[1] Columbia Univ Med Ctr, Div Infect Dis, New York, NY 10032 USA
[2] Univ Colorado Anschutz Med Campus, Aurora, CO USA
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2022年 / 66卷 / 12期
基金：
美国国家卫生研究院;
关键词：
human monkeypox virus; TPOXX; tecovirimat; CLINICAL CHARACTERISTICS; ST-246; SMALLPOX; PHARMACOKINETICS; DISEASE; SAFETY;
D O I：
10.1128/aac.01226-22
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Tecovirimat is an antiviral drug initially developed against variola virus (VARV) to treat smallpox infection. Due to its mechanism of action, it has activity against the family of orthopoxviruses, including vaccinia and the human monkeypox virus (HMPXV). Efficacy studies have thus far been limited to animal models, with human safety trials showing no serious adverse events. Currently approved by the FDA only for the treatment of smallpox, tecovirimat shows promise for the treatment of HMPXV. Tecovirimat has been prescribed via an expanded access for an investigational new drug protocol during the 2022 outbreak. This review will examine the literature surrounding tecovirimat's mechanism of action, pharmacokinetics, safety, efficacy, and potential for resistance.
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页数：8
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