Studies of the in Vitro Antibacterial Activities of Several Polyphenols against Clinical Isolates of Methicillin-Resistant Staphylococcus aureus

被引：66

作者：

Su, Yanli ^{[1
]}

Ma, Liyan ^{[2
]}

Wen, Yan ^{[1
]}

Wang, Hong ^{[1
]}

Zhang, Shuwen ^{[1
]}

机构：

[1] Capital Med Univ, Beijing Friendship Hosp, Dept Infect & Crit Care Med, Beijing 100050, Peoples R China

[2] Capital Med Univ, Beijing Friendship Hosp, Clin Lab Ctr, Beijing 100050, Peoples R China

来源：

MOLECULES | 2014年 / 19卷 / 08期

关键词：

methicillin-resistant Staphylococcus aureus; polyphenols; antibacterial activity; synergism; CHINESE MEDICINAL-PLANTS; MRSA; SYNERGY; AGENTS; FLAVONOIDS; INHIBITION; EXTRACTS;

D O I：

10.3390/molecules190812630

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In this study, we report the antibacterial activities of six polyphenols (i.e., luteolin, quercetin, scutellarin, apigenin, chlorogenic acid, and resveratrol) against 29 clinical isolates of methicillin-resistant Staphylococcus aureus (MRSA), and in vitro antibacterial activities of two-drug combinations. All of the MRSA strains evaluated were clinical isolates from patients with MRSA bacteremia. The antibacterial activities were determined by agar dilution method, and the two-drug antibacterial activities were determined by the checkerboard agar dilution method. It was found that luteolin, quercetin and resveratrol show obvious antibacterial activities against MRSA, and the results of two-drug antibacterial activity show either synergy or additivity, without evidences of antagonistic effects.

引用

页码：12630 / 12639

页数：10

共 23 条

[1] Plants as sources of new antimicrobials and resistance-modifying agents [J].

Abreu, Ana Cristina ;

McBain, Andrew J. ;

Simoes, Manuel .

NATURAL PRODUCT REPORTS, 2012, 29 (09) :1007-1021

[2] Bactericidal effect of grape seed extract on methicillin-resistant Staphylococcus aureus (MRSA) [J].

Al-Habib, Aamar ;

Al-Saleh, Esmaeil ;

Safer, Abdel-Majeed ;

Afzal, Mohammad .

JOURNAL OF TOXICOLOGICAL SCIENCES, 2010, 35 (03) :357-364

[3]

[Anonymous], 2012, METHODS DILUTION ANT

[4] Infection with vancomycin-resistant Staphylococcus aureus containing the vanA resistance gene [J].

Chang, S ;

Sievert, DM ;

Hageman, JC ;

Boulton, ML ;

Tenover, FC ;

Downes, FP ;

Shah, S ;

Rudrik, JT ;

Pupp, GR ;

Brown, WJ ;

Cardo, D ;

Fridkin, SK .

NEW ENGLAND JOURNAL OF MEDICINE, 2003, 348 (14) :1342-1347

[5] Facile and material-independent fabrication of poly(luteolin) coatings and their unimpaired antibacterial activity against Staphylococcus aureus after steam sterilization treatments [J].

Cheng, Jingya ;

Guan, Miao ;

Zhu, Jialiang ;

Wang, Changtao ;

Su, Lei ;

Zhang, Xueji .

POLYMER CHEMISTRY, 2014, 5 (14) :4211-4214

[6] SYNERGISTIC INTERACTIONS OF CIPROFLOXACIN AND EXTENDED-SPECTRUM BETA-LACTAMS OR AMINOGLYCOSIDES AGAINST MULTIPLY DRUG-RESISTANT PSEUDOMONAS-MALTOPHILIA [J].

CHOW, AW ;

WONG, J ;

BARTLETT, KH .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1988, 32 (05) :782-784

[7] Recent advances in understanding the antibacterial properties of flavonoids [J].

Cushnie, T. P. Tim ;

Lamb, Andrew J. .

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, 2011, 38 (02) :99-107

[8] Antimicrobial activity of flavonoids [J].

Cushnie, TPT ;

Lamb, AJ .

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, 2005, 26 (05) :343-356

[9] Polyphenols as antimicrobial agents [J].

Daglia, Maria .

CURRENT OPINION IN BIOTECHNOLOGY, 2012, 23 (02) :174-181

[10] Combating resistance in a challenging, changing environment [J].

Goldstein, F. W. .

CLINICAL MICROBIOLOGY AND INFECTION, 2007, 13 :2-6

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