Nerve growth factor stimulates MAPK via the low affinity receptor p75LNTR

被引:37
作者
Susen, K [1 ]
Heumann, R [1 ]
Blöchl, A [1 ]
机构
[1] Ruhr Univ Bochum, Fak Chem, D-44780 Bochum, Germany
关键词
nerve growth factor; mitogen-activated protein kinase; p75(LNTR); C-2-ceramide;
D O I
10.1016/S0014-5793(99)01628-2
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Apart from its high affinity receptor TrkA, were growth factor (NGF) can also stimulate the low affinity receptor p75(LNTR) and induce a Trk-independent signaling cascade. We examined the possible involvement of mitogen-activated protein kinase (MAPK) in this signaling pathway in neuronal cultures of the cerebellum of PZ-aged rats and PCNA cells; both cell types express p75(LNTR) but not TrkA. We found a fast and transient phosphorylation of p42- and p44-MAPK after stimulation with NGF or C-2-ceramide which proved to be sensitive to inhibition of MAPK kinase and protein kinase A (PKA). As stimulation with NGF also activated p21Ras it can be concluded that at least part of the observed MAPK activation was effected via p21Ras and via PKA, (C) 1999 Federation of European Biochemical Societies.
引用
收藏
页码:231 / 234
页数:4
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