Effective computational modeling of erythrocyte electro-deformation

被引：6

作者：

Nodargi, Nicola A. ^{[1
]}

Bisegna, Paolo ^{[1
]}

Caselli, Federica ^{[1
]}

机构：

[1] Univ Roma Tor Vergata, Dept Civil Engn & Comp Sci, I-00133 Rome, Italy

来源：

MECCANICA | 2017年 / 52卷 / 03期

关键词：

Electro-deformation; Maxwell stress tensor; Erythrocyte mechanics; Homogenization; Finite elements; Corotational formulation; DIELECTRIC-SPECTROSCOPY; OPTICAL TWEEZERS; SHELL ELEMENTS; CYTOSKELETON; MECHANICS; CELLS; SIMULATIONS; CYTOMETER; TISSUES; FORCES;

D O I：

10.1007/s11012-016-0424-0

中图分类号：

O3 [力学];

学科分类号：

08 ; 0801 ;

摘要：

Due to its crucial role in pathophysiology, erythrocyte deformability represents a subject of intense experimental and modeling research. Here a computational approach to electro-deformation for erythrocyte mechanical characterization is presented. Strong points of the proposed strategy are: (1) an accurate computation of the mechanical actions induced on the cell by the electric field, (2) a microstructurally-based continuum model of the erythrocyte mechanical behavior, (3) an original rotation-free shell finite element, especially suited to the application in hand. As proved by the numerical results, the developed tool is effective and sound, and can foster the role of electro-deformation in single-cell mechanical phenotyping.

引用

页码：613 / 631

页数：19

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