Novel membrane-based biotechnological alternative process for succinic acid production and chemical synthesis of bio-based poly (butylene succinate)

被引：41

作者：

Wang, Caixia ^{[1
,2
]}

Ming, Wei ^{[3
]}

Yan, Daojiang ^{[1
,2
]}

Zhang, Congcong ^{[3
]}

Yang, Maohua ^{[1
]}

Liu, Yilan ^{[1
,2
]}

Zhang, Yu ^{[4
]}

Guo, Baohua ^{[4
]}

Wan, Yinhua ^{[1
]}

Xing, Jianmin ^{[1
]}

机构：

[1] Chinese Acad Sci, Inst Proc Engn, Natl Key Lab Biochem Engn, Beijing 100190, Peoples R China

[2] Grad Univ Chinese Acad Sci, Beijing 100049, Peoples R China

[3] Beijing Forestry Univ, Dept Biol Sci & Technol, Beijing 100083, Peoples R China

[4] Tsinghua Univ, Inst Polymer Sci & Engn, Dept Chem Engn, Beijing 100084, Peoples R China

来源：

BIORESOURCE TECHNOLOGY | 2014年 / 156卷

基金：

美国国家科学基金会; 国家高技术研究发展计划(863计划);

关键词：

Succinic acid; Membrane separation; Integrated process; Poly (butylene succinate) synthesis; ESCHERICHIA-COLI; YIELD; TRANSFORMATIONS; ESTERIFICATION; DESIGN;

D O I：

10.1016/j.biortech.2013.12.043

中图分类号：

S2 [农业工程];

学科分类号：

0828 ;

摘要：

Succinic acid was produced in a novel membrane-based fermentation and separation integrated system. With this integrated system, product inhibition was alleviated by removing acids and replenishing fresh broth. High cell density maintain for a longer time from 75 to 130 h and succinic acid concentration increased from 53 to 73 g/L. In the developed separation process, succinic acid was crystallized at a recovery of 85-90%. The purity of the obtained succinic acid crystals reached 99.4% as found by HPLC and H-1 NMR analysis. A crystallization experiment indicated that among by-products glucose had a negative effect on succinic acid crystallization. Poly (butylene succinate) (PBS) was synthesized using the purified succinic acid and H-1 NMR analysis confirmed that the composition of the synthesized PBS is in agreement with that from petro-based succinic acid. Crown Copyright (C) 2013 Published by Elsevier Ltd. All rights reserved.

引用

页码：6 / 13

页数：8

共 28 条

[1] Technology development for the production of biobased products from biorefinery carbohydrates-the US Department of Energy's "Top 10" revisited
Bozell, Joseph J.
Petersen, Gene R.
[J]. GREEN CHEMISTRY, 2010, 12 (04) : 539 - 554
[2] Downstream processing of biotechnological produced succinic acid
Cheng, Ke-Ke
Zhao, Xue-Bing
Zeng, Jing
Wu, Ru-Chun
Xu, Yun-Zhen
Liu, De-Hua
Zhang, Jian-An
[J]. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 2012, 95 (04) : 841 - 850
[3] Biotechnological production of succinic acid: current state and perspectives
Cheng, Ke-Ke
Zhao, Xue-Bing
Zeng, Jing
Zhang, Jian-An
[J]. BIOFUELS BIOPRODUCTS & BIOREFINING-BIOFPR, 2012, 6 (03): : 302 - 318
[4] Catalytic performance of carbonaceous materials in the esterification of succinic acid
Clark, James H.
Budarin, Vitaly
Dugmore, Thomas
Luque, Rafael
Macquarrie, Duncan J.
Strelko, Volodimir
[J]. CATALYSIS COMMUNICATIONS, 2008, 9 (08) : 1709 - 1714
[5] Succinic acid from renewable resources as a C4 building-block chemical-a review of the catalytic possibilities in aqueous media
Delhomme, Clara
Weuster-Botz, Dirk
Kuehn, Fritz E.
[J]. GREEN CHEMISTRY, 2009, 11 (01) : 13 - 26
[6] Actinobacillus succinogenes sp. nov., a novel succinic-acid-producing strain from the bovine rumen
Guettler, MV
Rumler, D
Jain, MK
[J]. INTERNATIONAL JOURNAL OF SYSTEMATIC BACTERIOLOGY, 1999, 49 : 207 - 216
[7] Metabolic flux analysis and metabolic engineering of microorganisms
Kim, Hyun Uk
Kim, Tae Yong
Lee, Sang Yup
[J]. MOLECULAR BIOSYSTEMS, 2008, 4 (02) : 113 - 120
[8] Reaction kinetics for the heterogeneously catalyzed esterification of succinic acid with ethanol
Kolah, Aspi K.
Asthana, Navinchandra S.
Vu, Dung T.
Lira, Carl T.
Miller, Dennis J.
[J]. INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH, 2008, 47 (15) : 5313 - 5317
[9] Kinetic evaluation of products inhibition to succinic acid producers Escherichia coli NZN111, AFP111, BL21, and Actinobacillus succinogenes 130ZT
Li, Qiang
Wang, Dan
Wu, Yong
Yang, Maohua
Li, Wangliang
Xing, Jianmin
Su, Zhiguo
[J]. JOURNAL OF MICROBIOLOGY, 2010, 48 (03) : 290 - 296
[10] Li Qiang, 2010, Bioresour Technol, V101, P3292, DOI 10.1016/j.biortech.2009.12.064

← 1 2 3 →