Novel membrane-based biotechnological alternative process for succinic acid production and chemical synthesis of bio-based poly (butylene succinate)

被引：41

作者：

Wang, Caixia ^{[1
,2
]}

Ming, Wei ^{[3
]}

Yan, Daojiang ^{[1
,2
]}

Zhang, Congcong ^{[3
]}

Yang, Maohua ^{[1
]}

Liu, Yilan ^{[1
,2
]}

Zhang, Yu ^{[4
]}

Guo, Baohua ^{[4
]}

Wan, Yinhua ^{[1
]}

Xing, Jianmin ^{[1
]}

机构：

[1] Chinese Acad Sci, Inst Proc Engn, Natl Key Lab Biochem Engn, Beijing 100190, Peoples R China

[2] Grad Univ Chinese Acad Sci, Beijing 100049, Peoples R China

[3] Beijing Forestry Univ, Dept Biol Sci & Technol, Beijing 100083, Peoples R China

[4] Tsinghua Univ, Inst Polymer Sci & Engn, Dept Chem Engn, Beijing 100084, Peoples R China

来源：

BIORESOURCE TECHNOLOGY | 2014年 / 156卷

基金：

美国国家科学基金会; 国家高技术研究发展计划(863计划);

关键词：

Succinic acid; Membrane separation; Integrated process; Poly (butylene succinate) synthesis; ESCHERICHIA-COLI; YIELD; TRANSFORMATIONS; ESTERIFICATION; DESIGN;

D O I：

10.1016/j.biortech.2013.12.043

中图分类号：

S2 [农业工程];

学科分类号：

0828 ;

摘要：

Succinic acid was produced in a novel membrane-based fermentation and separation integrated system. With this integrated system, product inhibition was alleviated by removing acids and replenishing fresh broth. High cell density maintain for a longer time from 75 to 130 h and succinic acid concentration increased from 53 to 73 g/L. In the developed separation process, succinic acid was crystallized at a recovery of 85-90%. The purity of the obtained succinic acid crystals reached 99.4% as found by HPLC and H-1 NMR analysis. A crystallization experiment indicated that among by-products glucose had a negative effect on succinic acid crystallization. Poly (butylene succinate) (PBS) was synthesized using the purified succinic acid and H-1 NMR analysis confirmed that the composition of the synthesized PBS is in agreement with that from petro-based succinic acid. Crown Copyright (C) 2013 Published by Elsevier Ltd. All rights reserved.

引用

页码：6 / 13

页数：8

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