Chemical constituents from the culture of the fungus Hericium alpestre

被引：7

作者：

Li, Lu-Ning ^{[1
]}

Wang, Lei ^{[2
]}

Guo, Xiu-Li ^{[2
]}

机构：

[1] Shandong Univ, Sch Pharmaceut Sci, Dept Nat Med Chem, Jinan 250012, Shandong, Peoples R China

[2] Shandong Univ, Sch Pharmaceut Sci, Dept Pharmacol, Jinan 250012, Shandong, Peoples R China

来源：

JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH | 2019年 / 21卷 / 08期

关键词：

Hericiaceae; Hericium alpestre; secondary metabolites; cytotoxicity; MUSHROOM;

D O I：

10.1080/10286020.2018.1483346

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Two new compounds herialpins A-B (1-2), along with eleven known compounds, were isolated from the culture of fungus Hericium alpestre. The structures were elucidated by 1D and 2D NMR data, ESI-MS and X-ray crystallographic analysis. Compounds 1-2 were assayed for their cytotoxicity against three tumor cell lines compared with the known compound 3. Compounds 1 and 2 were found with modest activity, while compound 3 exhibits stronger selective inhibitory activity against A549 and HT-29 cells with IC50 values of 15.1 and 20.1 mu mol/L, respectively. The pyrano[3,4-g]chromene-4,6-dione moiety in compound 3 should be responsible for the stronger selective inhibitory activity. [GRAPHICS] .

引用

页码：735 / 741

页数：7

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