Advances in our understanding of gout as an auto-inflammatory disease

被引：51

作者：

Bodofsky, Shari ^{[1
]}

Merriman, Tony R. ^{[2
]}

Thomas, T. J. ^{[3
]}

Schlesinger, Naomi ^{[3
]}

机构：

[1] Rutgers Robert Wood Johnson Med Sch, New Brunswick, NJ 08901 USA

[2] Univ Otago, Dept Biochem, Dunedin, New Zealand

[3] Rutgers Robert Wood Johnson Med Sch, Dept Med, Div Rheumatol, New Brunswick, NJ USA

来源：

SEMINARS IN ARTHRITIS AND RHEUMATISM | 2020年 / 50卷 / 05期

关键词：

Gout; Molecular; Genetic; Autoinflammatory; Inflammasome; NECROSIS-FACTOR-ALPHA; MONOCYTE CHEMOATTRACTANT PROTEIN-1; CARD8; RS2043211; POLYMORPHISM; CRYSTAL-INDUCED INFLAMMATION; INDUCED IL-1-BETA RELEASE; URIC-ACID CONCENTRATIONS; TRANSMEMBRANE TNF-ALPHA; SOLUBLE CD14 LEVELS; SERUM URATE LEVELS; RHEUMATOID-ARTHRITIS;

D O I：

10.1016/j.semarthrit.2020.06.015

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Gout, the most common inflammatory arthritis, is the result of hyperuricemia and inflammation induced by monosodium urate (MSU) crystal deposition. However, most people with hyperuricemia will never develop gout, implying a molecular-genetic contribution to the development of gout. Recent genomic studies reveal links between certain genetic variations and gout. We highlight recent advances in our understanding of gout as an auto-inflammatory disease. We review the auto-inflammatory aspects of gout, including the inflammasome and thirteen gout-associated inflammatory-pathway genes and associated comorbidities. This information provides important insights into emerging immune-modulating targets in the management of gout, and future novel therapeutic targets in gout treatment. Cumulatively, this has important implications for treating gout as an auto-inflammatory disease, as opposed to a purely metabolic disease. (C) 2020 Elsevier Inc. All rights reserved.

引用

页码：1089 / 1100

页数：12

共 184 条

[1] Polymorphisms and expression of inflammasome genes are associated with the development and severity of rheumatoid arthritis in Brazilian patients [J].

Addobbati, Catarina ;

Alves da Cruz, Heidi Lacerda ;

Adelino, Jose Eduardo ;

Melo Tavares Ramos, Amanda Luize ;

Fragoso, Thiago Sotero ;

Domingues, Alexandre ;

Branco Pinto Duarte, Angela Luiza ;

Ribeiro Oliveira, Rene Donizeti ;

Louzada-Junior, Paulo ;

Donadi, Eduardo Antonio ;

Pontillo, Alessandra ;

Silva, Jaqueline de Azevedo ;

Crovella, Sergio ;

Sandrin-Garcia, Paula .

INFLAMMATION RESEARCH, 2018, 67 (03) :255-264

[2] Recent Insights into the Molecular Mechanisms Underlying Pyroptosis and Gasdermin Family Functions [J].

Aglietti, Robin A. ;

Dueber, Erin C. .

TRENDS IN IMMUNOLOGY, 2017, 38 (04) :261-271

[3] Rapid induction of peroxisome proliferator-activated receptor γ expression in human monocytes by monosodium urate monohydrate crystals [J].

Akahoshi, T ;

Namai, R ;

Murakami, Y ;

Watanabe, M ;

Matsui, T ;

Nishimura, A ;

Kitasato, H ;

Kameya, T ;

Kondo, H .

ARTHRITIS AND RHEUMATISM, 2003, 48 (01) :231-239

[4] Transmembrane TNF-α is sufficient for articular inflammation and hypernociception in a mouse model of gout [J].

Amaral, Flavio A. ;

Bastos, Leandro F. S. ;

Oliveira, Thiago H. C. ;

Dias, Ana C. F. ;

Oliveira, Vivian L. S. ;

Tavares, Livia D. ;

Costa, Vivian V. ;

Galvao, Izabela ;

Soriani, Frederico M. ;

Szymkowski, David E. ;

Ryffel, Bernhard ;

Souza, Danielle G. ;

Teixeira, Mauro M. .

EUROPEAN JOURNAL OF IMMUNOLOGY, 2016, 46 (01) :204-211

[5] A polymorphism* in the 5′ flanking region of the CD14 gene is associated with circulating soluble CD14 levels and with total serum immunoglobulin E [J].

Baldini, M ;

Lohman, IC ;

Halonen, M ;

Erickson, RP ;

Holt, PG ;

Martinez, FD .

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 1999, 20 (05) :976-983

[6] Toll-like receptor 4 inhibition reduces vascular inflammation in spontaneously hypertensive rats [J].

Bomfim, G. F. ;

Echem, C. ;

Martins, C. B. ;

Costa, T. J. ;

Sartoretto, S. M. ;

Dos Santos, R. A. ;

Oliveira, M. A. ;

Akamine, E. H. ;

Fortes, Z. B. ;

Tostes, R. C. ;

Webb, R. C. ;

Carvalho, M. H. C. .

LIFE SCIENCES, 2015, 122 :1-7

[7] Genomic dissection of 43 serum urate-associated loci provides multiple insights into molecular mechanisms of urate control [J].

Boocock, James ;

Leask, Megan ;

Okada, Yukinori ;

Matsuo, Hirotaka ;

Kawamura, Yusuke ;

Shi, Yongyong ;

Li, Changgui ;

Mount, David B. ;

Mandal, Asim K. ;

Wang, Weiqing ;

Cadzow, Murray ;

Gosling, Anna L. ;

Major, Tanya J. ;

Horsfield, Julia A. ;

Choi, Hyon K. ;

Fadason, Tayaza ;

O'Sullivan, Justin ;

Stahl, Eli A. ;

Merriman, Tony R. .

HUMAN MOLECULAR GENETICS, 2020, 29 (06) :923-943

[8] Purinergic (P2X7) receptor activation of microglia induces cell death via an interleukin-1-independent mechanism [J].

Brough, D ;

Le Feuvre, RA ;

Iwakura, Y ;

Rothwell, NJ .

MOLECULAR AND CELLULAR NEUROSCIENCE, 2002, 19 (02) :272-280

[9] Inflammasomes: mechanism of assembly, regulation and signalling [J].

Broz, Petr ;

Dixit, Vishva M. .

NATURE REVIEWS IMMUNOLOGY, 2016, 16 (07) :407-420

[10]

Buell GN, 1998, RECEPTOR CHANNEL, V5, P347

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