The human TLR4 variant D299G mediates inflammation-associated cancer progression in the intestinal epithelium

被引：10

作者：

Cario, Elke ^{[1
]}

机构：

[1] Univ Duisburg Essen, Sch Med, Univ Hosp Essen, Div Gastroenterol & Hepatol, Essen, Germany

来源：

ONCOIMMUNOLOGY | 2013年 / 2卷 / 07期

关键词：

Toll-like receptors; cancer-associated inflammation; innate immunity; colon cancer; pattern-recognition receptors; tumor microenvironment; lipopolysaccharide; intestinal epithelial cells; metastasis; RECEPTOR; 4; TOLL; CELLS;

D O I：

10.4161/onci.24890

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Homeostatic TLR4 signaling protects the intestinal epithelium in health. Evidence suggests that perturbed TLR4 signaling is linked to carcinogenesis. We have recently demonstrated that the common human TLR4 variant D299G exerts pro-inflammatory effects and drives malignant tumor progression in human colon cancer.

引用

页数：2

共 10 条

[1] TLR4 mutations are associated with endotoxin hyporesponsiveness in humans [J].

Arbour, NC ;

Lorenz, E ;

Schutte, BC ;

Zabner, J ;

Kline, JN ;

Jones, M ;

Frees, K ;

Watt, JL ;

Schwartz, DA .

NATURE GENETICS, 2000, 25 (02) :187-+

[2] Differential alteration in intestinal epithelial cell expression of Toll-like receptor 3 (TLR3) and TLR4 in inflammatory bowel disease [J].

Cario, E ;

Podolsky, DK .

INFECTION AND IMMUNITY, 2000, 68 (12) :7010-7017

[3] The role of the Toll receptor pathway in susceptibility to inflammatory bowel diseases [J].

De Jager, P. L. ;

Franchimont, D. ;

Waliszewska, A. ;

Bitton, A. ;

Cohen, A. ;

Langelier, D. ;

Belaiche, J. ;

Vermeire, S. ;

Farwell, L. ;

Goris, A. ;

Libioulle, C. ;

Jani, N. ;

Dassopoulos, T. ;

Bromfield, G. P. ;

Dubois, B. ;

Cho, J. H. ;

Brant, S. R. ;

Duerr, R. H. ;

Yang, H. ;

Rotter, J. I. ;

Silverberg, M. S. ;

Steinhart, A. H. ;

Daly, M. J. ;

Podolsky, D. K. ;

Louis, E. ;

Hafler, D. A. ;

Rioux, J. D. .

GENES AND IMMUNITY, 2007, 8 (05) :387-397

[4] Exome and whole-genome sequencing of esophageal adenocarcinoma identifies recurrent driver events and mutational complexity [J].

Dulak, Austin M. ;

Stojanov, Petar ;

Peng, Shouyong ;

Lawrence, Michael S. ;

Fox, Cameron ;

Stewart, Chip ;

Bandla, Santhoshi ;

Imamura, Yu ;

Schumacher, Steven E. ;

Shefler, Erica ;

McKenna, Aaron ;

Carter, Scott L. ;

Cibulskis, Kristian ;

Sivachenko, Andrey ;

Saksena, Gordon ;

Voet, Douglas ;

Ramos, Alex H. ;

Auclair, Daniel ;

Thompson, Kristin ;

Sougnez, Carrie ;

Onofrio, Robert C. ;

Guiducci, Candace ;

Beroukhim, Rameen ;

Zhou, Zhongren ;

Lin, Lin ;

Lin, Jules ;

Reddy, Rishindra ;

Chang, Andrew ;

Landrenau, Rodney ;

Pennathur, Arjun ;

Ogino, Shuji ;

Luketich, James D. ;

Golub, Todd R. ;

Gabriel, Stacey B. ;

Lander, Eric S. ;

Beer, David G. ;

Godfrey, Tony E. ;

Getz, Gad ;

Bass, Adam J. .

NATURE GENETICS, 2013, 45 (05) :478-U37

[5] Toll-like Receptor 4 Variant D299G Induces Features of Neoplastic Progression in Caco-2 Intestinal Cells and Is Associated With Advanced Human Colon Cancer [J].

Eyking, Annette ;

Ey, Birgit ;

Ruenzl, Michael ;

Roig, Andres I. ;

Reis, Henning ;

Schmid, Kurt W. ;

Gerken, Guido ;

Podolsky, Daniel K. ;

Cario, Elke .

GASTROENTEROLOGY, 2011, 141 (06) :2154-2165

[6] Toll-like receptor-4 promotes the development of colitis-associated colorectal tumors [J].

Fukata, Masayuki ;

Chen, Anli ;

Vamadevan, Arunan S. ;

Cohen, Jason ;

Breglio, Keith ;

Krishnareddy, Suneeta ;

Hsu, David ;

Xu, Ruiliang ;

Harpaz, Noam ;

Dannenberg, Andrew J. ;

Subbaramaiah, Kotha ;

Cooper, Harry S. ;

Itzkowitz, Steven H. ;

Abreu, Maria T. .

GASTROENTEROLOGY, 2007, 133 (06) :1869-1881

[7] A functional polymorphism of toll-like receptor 4 gene increases risk of gastric carcinoma and its precursors [J].

Hold, Georgina L. ;

Rabkin, Charles S. ;

Chow, Wong-Ho ;

Smith, Malcolm G. ;

Gammon, Marilie D. ;

Risch, Harvey A. ;

Vaughan, Thomas L. ;

McColl, Kenneth E. L. ;

Lissowska, Jolanta ;

Zatonski, Witold ;

Schoenberg, Janet B. ;

Blot, William J. ;

Mowat, N. Ashley G. ;

Fraumeni, Joseph F., Jr. ;

El-Omar, Emad M. .

GASTROENTEROLOGY, 2007, 132 (03) :905-912

[8] Toll-like Receptor 4 Is Expressed on Intestinal Stem Cells and Regulates Their Proliferation and Apoptosis via the p53 Up-regulated Modulator of Apoptosis [J].

Neal, Matthew D. ;

Sodhi, Chhinder P. ;

Jia, Hongpeng ;

Dyer, Mitchell ;

Egan, Charlotte E. ;

Yazji, Ibrahim ;

Good, Misty ;

Afrazi, Amin ;

Marino, Ryan ;

Slagle, Dennis ;

Ma, Congrong ;

Branca, Maria F. ;

Prindle, Thomas, Jr. ;

Grant, Zachary ;

Ozolek, John ;

Hackam, David J. .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2012, 287 (44) :37296-37308

[9] Structural Analyses of Human Toll-like Receptor 4 Polymorphisms D299G and T399I [J].

Ohto, Umeharu ;

Yamakawa, Natsuko ;

Akashi-Takamura, Sachiko ;

Miyake, Kensuke ;

Shimizu, Toshiyuki .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2012, 287 (48) :40611-40617

[10] Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis [J].

Rakoff-Nahoum, S ;

Paglino, J ;

Eslami-Varzaneh, F ;

Edberg, S ;

Medzhitov, R .

CELL, 2004, 118 (02) :229-241

← 1 →