Docking of Selected Natural Polyphenols to ARF Activated A1 Subunit of Cholera Toxin

被引：0
|
作者：
Podlipnik, Crtomir [1 ]
机构：
[1] Fac Chem & Chem Technol, Ljubljana 1000, Slovenia
来源：
ACTA CHIMICA SLOVENICA | 2009年 / 56卷 / 01期
关键词：
Cholera Toxin; ADP-ribosylation; natural polyphenols; molecular docking; INDUCED FLUID ACCUMULATION; HEAT-LABILE ENTEROTOXIN; PROTECTIVE ACTIVITY; ESCHERICHIA-COLI; ACCURATE DOCKING; DESIGN; TEA; PROTEIN; GLIDE; INFECTION;
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Natural products containing polyphenols are traditional drugs to treat diarrheal diseases such as cholera. One of the suggested mechanisms of action of these compounds is inhibition of ADP-ribosylation induced by cholera toxin. In this study we used docking methods to explore the ability of polyphenols to bind to the binding site for NAD+ of the CTA(1):ARF(6)-GTP complex (Science 2005, 309, 1093). Docking results show that catechins may enter into the binding site of CTA(1). Epigallocatechin gallate, theaflavin-3,3'-digallate, 1,2,3,6-tetra-O-galloyl-D-glucose are the best binders among studied compounds.
引用
收藏
页码：156 / 165
页数：10
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