The Dynamics of X-Chromosome Inactivation in Mouse Development

被引：8
|
作者：
Kamikawa, Yasunao [1 ]
Donohoe, Mary E. [1 ]
机构：
[1] Weill Cornell Med Coll, Dept Neurosci, Dept Cell & Dev Biol, Burke Med Res Inst, White Plains, NY 10605 USA
来源：
MOLECULAR REPRODUCTION AND DEVELOPMENT | 2014年 / 81卷 / 02期
关键词：
XIST RNA; DOSAGE COMPENSATION; NONCODING RNA; SEX-CHROMATIN; CELL-LINES; GERM-CELLS; TSIX; FEMALE; GENE; TRANSCRIPTION;
D O I：
10.1002/mrd.22282
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Mammals utilize chromosomes to determine sex, but this leads to a problem with gene inequality. In the mouse, gene dosage disparity is evident by the presence of two X chromosomes in the female and a single X and Y chromosome in the male. To balance the X-linked transcriptional dose difference between the sexes, one of the two female X-chromosomes is silenced to equal the dose of XY malesa crucial developmental process known as X-chromosome inactivation. Here we highlight dosage compensation in the mouse, and detail the known mechanisms to set and erase these epigenetic marks during development. Mol. Reprod. Dev. 81: 141-147, 2014. (c) 2013 Wiley Periodicals, Inc.
引用
收藏
页码：141 / 147
页数：7
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