GAP-independent functions of DLC1 in metastasis

被引：31

作者：

Barras, David ^{[1
]}

Widmann, Christian ^{[1
]}

机构：

[1] Univ Lausanne, Dept Physiol, CH-1005 Lausanne, Switzerland

来源：

CANCER AND METASTASIS REVIEWS | 2014年 / 33卷 / 01期

基金：

瑞士国家科学基金会;

关键词：

DLC1; RhoGAP; GAP-independent; Migration; Invasion; Metastasis; GTPASE-ACTIVATING PROTEIN; CANCER; DLC1; TUMOR-SUPPRESSOR GENE; FOCAL ADHESION-LOCALIZATION; CONTROLS CELL-MIGRATION; RHO-GTPASES; ALPHA-CATENIN; PLC-DELTA(1)-BINDING PROTEIN; ADHERENS JUNCTIONS; CARCINOMA CELLS;

D O I：

10.1007/s10555-013-9458-0

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Metastases are responsible for most cancer-related deaths. One of the hallmarks of metastatic cells is increased motility and migration through extracellular matrixes. These processes rely on specific small GTPases, in particular those of the Rho family. Deleted in liver cancer-1 (DLC1) is a tumor suppressor that bears a RhoGAP activity. This protein is lost in most cancers, allowing malignant cells to proliferate and disseminate in a Rho-dependent manner. However, DLC1 is also a scaffold protein involved in alternative pathways leading to tumor and metastasis suppressor activities. Recently, substantial information has been gathered on these mechanisms and this review is aiming at describing the potential and known alternative GAP-independent mechanisms allowing DLC1 to impair migration, invasion, and metastasis formation.

引用

页码：87 / 100

页数：14

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