The roles of Jumonji-type oxygenases in human disease

被引：130
作者：
Johansson, Catrine [1 ]
Tumber, Anthony [1 ]
Che, KaHing [1 ,2 ]
Cain, Peter [2 ]
Nowak, Radoslaw [1 ,2 ,3 ]
Gileadi, Carina [1 ]
Oppermann, Udo [1 ,2 ,3 ]
机构：
[1] Univ Oxford, Struct Genom Consortium, Headington OX3 7DQ, England
[2] Nuffield Dept Orthopaed Rheumatol & Musculoskelet, NIHR Oxford Biomed Res Unit, Botnar Res Ctr, Oxford OX3 7LD, England
[3] Ind Doctorate Ctr SABS IDC Oxford, Oxford, England
来源：
EPIGENOMICS | 2014年 / 6卷 / 01期
基金：
英国生物技术与生命科学研究理事会; 英国惠康基金;
关键词：
chromatin modification; epigenetic; histone demethylation; Jumonji; lysine methylation; oxygenases; HUMAN ALKB HOMOLOG; MYC TARGET GENE; HISTONE DEMETHYLASE JMJD1A; LINKED MENTAL-RETARDATION; REGULATES CELL-PROLIFERATION; TRANSCRIPTION FACTOR OSTERIX; ANTERIOR TEMPORAL NEOCORTEX; VITAMIN-D-RECEPTOR; RNA-POLYMERASE-II; JMJC-DOMAIN;
D O I：
10.2217/epi.13.79
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
The iron- and 2-oxoglutarate-dependent oxygenases constitute a phylogenetically conserved class of enzymes that catalyze hydroxylation reactions in humans by acting on various types of substrates, including metabolic intermediates, amino acid residues in different proteins and various types of nucleic acids. The discovery of jumonji (Jmj), the founding member of a class of Jmj-type chromatin modifying enzymes and transcriptional regulators, has culminated in the discovery of several branches of histone lysine demethylases, with essential functions in regulating the epigenetic landscape of the chromatin environment. This work has now been considerably expanded into other aspects of epigenetic biology and includes the discovery of enzymatic steps required for methyl-cytosine demethylation as well as modification of RNA and ribosomal proteins. This overview aims to summarize the current knowledge on the human Jmj-type enzymes and their involvement in human pathological processes, including development, cancer, inflammation and metabolic diseases.
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收藏
页码：89 / 120
页数：32
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