Surface-Enhanced Raman Scattering Tags for Rapid and Homogeneous Detection of Circulating Tumor Cells in the Presence of Human Whole Blood

被引：284
作者：
Sha, Michael Y. [1 ]
Xu, Hongxia [1 ]
Natan, Michael J. [1 ]
Cromer, Remy [1 ]
机构：
[1] Oxonica Inc, Mountain View, CA 94043 USA
来源：
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2008年 / 130卷 / 51期
关键词：
D O I：
10.1021/ja804494m
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A novel, homogeneous SERS-based cell detection assay was developed for rapid and direct enumeration of circulating tumor cells in the presence of whole blood. Magnetic beads and SERS tags were respectively conjugated to EpCAM and her2 antibodies for the capture and detection of approximately 50 tumor cells/mL in the presence of whole blood in less than 1 h.
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页码：17214 / +
页数：3
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