Activity of retapamulin (SB-275833), a novel pleuromutilin, against selected resistant gram-positive cocci

被引：102
作者：
Jones, Ronald N.
Fritsche, Thomas R.
Sader, Helio S.
Ross, James E.
机构：
[1] JMI Labs Inc, N Liberty, IA 52317 USA
[2] Tufts Univ, Sch Med, Boston, MA 02111 USA
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2006年 / 50卷 / 07期
关键词：
D O I：
10.1128/AAC.01432-05
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Retapamulin (SB-275833), the first pleuromutilin to be developed for human topical use, was tested against a selected population of staphylococci and beta-hemolytic streptococci. The MIC,, results for retapamulin were 0.12 mu g/ml for Staphylococcus aureus and <= 0.03 mu g/ml for Streptococcus pyogenes; no cross-resistance was observed for organism subsets resistant to oxacillin, erythromycin, or mupirocin.
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页码：2583 / 2586
页数：4
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