Synthesis of enantiopure cis- and trans-2,3-disubstituted piperidines

被引：16

作者：

Agami, C ^{[1
]}

Dechoux, L ^{[1
]}

Ménard, C ^{[1
]}

Hebbe, S ^{[1
]}

机构：

[1] Univ Paris 06, UMR 7611, CNRS, Lab Synth Asymetr, F-75005 Paris, France

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2002年 / 67卷 / 21期

关键词：

D O I：

10.1021/jo025955+

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of enantiopure cis- and trans-2,3-disubstituted piperidines 4 is described. The key step of the synthesis involves the stereoselective reduction of chiral nonracemic lactams 2 by using (BH3Me2S)-Me-.. A rationalization of the stereoselectivity is presented.

引用

页码：7573 / 7576

页数：4

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