Paracrine effects of TLR4-polarised mesenchymal stromal cells are mediated by extracellular vesicles

被引：10

作者：

Zeuner, Marie-Theres ^{[1
]}

Patel, Ketan ^{[2
,3
]}

Denecke, Bernd ^{[4
]}

Giebel, Bernd ^{[5
]}

Widera, Darius ^{[1
]}

机构：

[1] Univ Reading, Reading Sch Pharm, Stem Cell Biol & Regenerat Med Grp, Whiteknights Campus,POB 226, Reading RG6 6AP, Berks, England

[2] Univ Reading, Sch Biol Sci, Whiteknights Campus, Reading RG6 6AP, Berks, England

[3] Univ Freiburg, Freiburg Inst Adv Studies FRIAS, Albertstr 19, D-79104 Freiburg, Germany

[4] Rhein Westfal TH Aachen, Interdisciplinary Ctr Clin Res Aachen IZKF Aachen, Aachen, Germany

[5] Univ Duisburg Essen, Univ Hosp Essen, Inst Transfus Med, Essen, Germany

来源：

JOURNAL OF TRANSLATIONAL MEDICINE | 2016年 / 14卷

关键词：

TLR4; LPS; Exosomes; Microvesicles; Extracellular vesicles; MSCs; Preconditioning; TOLL-LIKE RECEPTORS; STEM-CELLS; EXOSOMES; LPS; TOLL-LIKE-RECEPTOR-4; IMMUNOMODULATION; MICROVESICLES; ENDOCYTOSIS; PROTECTION; MECHANISM;

D O I：

10.1186/s12967-016-0794-z

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Mesenchymal stromal cells (MSCs) are adult stem cells able to give rise to bone, cartilage and fat cells. In addition, they possess immunomodulatory and immunosuppressive properties that are mainly mediated through secretion of extracellular vesicles (EVs). In a previous issue of Journal of Translational Medicine, Ti and colleagues demonstrated that preconditioning of MSCs with bacterial lipopolysaccharides results in secretion of EVs that can polarise macrophages towards anti-inflammatory M2 phenotype. Moreover, the authors suggest that EVs of lipopolysaccharide (LPS)-treated MSCs are superior to EVs of untreated MSCs concerning their ability to support wound healing. Our commentary critically discusses parallel efforts of other laboratories to generate conditioned media from stem cells for therapeutic applications, and highlights impact and significance of the study of Ti et al. Finally, we summarise its limitations and spotlight areas that need to be addressed to better define the underlying molecular mechanisms.

引用

页数：4

共 39 条

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