Propylthiouracil-Induced Leucocytoclastic Vasculitis With Pulmonary Hemorrhage Treated With Plasmapheresis

被引：8

作者：

Irani, Farzan ^{[1
]}

Elkambergy, Hussam ^{[1
]}

Naraharisetty, Kalpana ^{[1
]}

Jamal, Raheel ^{[2
]}

机构：

[1] St Vincent Mercy Med Ctr, Dept Internal Med, Toledo, OH USA

[2] St Vincent Mercy Med Ctr, Dept Pulm & Crit Care Med, Toledo, OH USA

来源：

AMERICAN JOURNAL OF THE MEDICAL SCIENCES | 2009年 / 337卷 / 06期

关键词：

Propylthiouracil; Antineutrophil cytoplasmic; Vasculitis; Plasmapheresis; ANTI-MPO; ANTIBODIES; PTU;

D O I：

10.1097/MAJ.0b013e31819241a2

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Propylthiouracil (PTU) can effectuate antineutrophil cytoplasmic antibodies (ANCA)-positive vasculitis. We report a case of severe, PTU-induced leucocytoclastic vasculitis with diffuse pulmonary hemorrhage within a month of initiating PTU. Emergent plasmapheresis was initiated with excellent clinical response. A clinical for this potential side effect coupled with early cessation of the drug is generally adequate. Clinical manifestations, posited pathogenetic mechanisms, and therapeutic strategies, including the role of plasmapheresis. are discussed.

引用

页码：470 / 472

页数：3

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