The lung in rheumatoid arthritis, cause or consequence?

被引:53
作者
Chatzidionisyou, Aikaterini [1 ]
Catrina, Anca I. [1 ]
机构
[1] Karolinska Univ Hosp & Inst, Rheumatol Unit, Dept Med, Stockholm, Sweden
基金
瑞典研究理事会;
关键词
anticitrullinated protein antibodies; lungs; rheumatoid arthritis; rheumatoid factor; RESOLUTION COMPUTED-TOMOGRAPHY; OBSTRUCTIVE PULMONARY-DISEASE; CYCLIC CITRULLINATED PEPTIDE; USUAL INTERSTITIAL PNEUMONIA; ANTIBODIES PRECEDE; LYMPHOID-TISSUE; AUTOANTIBODIES; COHORT; AIRWAY; RISK;
D O I
10.1097/BOR.0000000000000238
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Purpose of reviewRecent discoveries implicate the lungs as a possible extra-articular mucosal site for initiating rheumatoid arthritis-associated immunity.Recent findingsIndividuals at risk for developing arthritis and patients with early untreated rheumatoid arthritis show signs of lung involvement on high-resolution computer tomography. Rheumatoid arthritis-associated antibodies are present in patients with respiratory complains such as bronchiectasis and unexplained dyspnea even in the absence of joint disease and might predict future development of rheumatoid arthritis in these patients. Rheumatoid arthritis-associated antibodies are detected in the sputum of individuals at risk for developing rheumatoid arthritis but not yet having disease. Signs of bronchial mucosal inflammation with germinal center formation and local production of antibodies have been described in patients with early untreated rheumatoid arthritis. Shared antigenic targets have been identified and characterized in the lungs and joints of rheumatoid arthritis patients.SummaryRecent findings support an important role for the lung as a mucosal extra-articular place were inflammation induced by external triggers (such as smoking) leads to tolerance break and generation of rheumatoid arthritis-specific immunity already before disease onset with only secondary targeting of the joints.
引用
收藏
页码:76 / 82
页数:7
相关论文
共 65 条
[1]  
AHO K, 1991, J RHEUMATOL, V18, P1282
[2]  
Aletaha D, 2010, ANN RHEUM DIS, V69, P1580, DOI [10.1136/ard.2010.138461, 10.1002/art.27584]
[3]   Anti-cyclic citrullinated peptide-2 (CCP2) autoantibodies and extra-articular manifestations in Greek patients with rheumatoid arthritis [J].
Alexiou, Ioannis ;
Germenis, Anastasios ;
Koutroumpas, Athanasios ;
Kontogianni, Anastasia ;
Theodoridou, Katerina ;
Sakkas, Lazaros I. .
CLINICAL RHEUMATOLOGY, 2008, 27 (04) :511-513
[4]   THE AMERICAN-RHEUMATISM-ASSOCIATION 1987 REVISED CRITERIA FOR THE CLASSIFICATION OF RHEUMATOID-ARTHRITIS [J].
ARNETT, FC ;
EDWORTHY, SM ;
BLOCH, DA ;
MCSHANE, DJ ;
FRIES, JF ;
COOPER, NS ;
HEALEY, LA ;
KAPLAN, SR ;
LIANG, MH ;
LUTHRA, HS ;
MEDSGER, TA ;
MITCHELL, DM ;
NEUSTADT, DH ;
PINALS, RS ;
SCHALLER, JG ;
SHARP, JT ;
WILDER, RL ;
HUNDER, GG .
ARTHRITIS AND RHEUMATISM, 1988, 31 (03) :315-324
[5]   Morphologic and quantitative assessment of CD20+ B cell infiltrates in rheumatoid arthritis-associated nonspecific interstitial pneumonia and usual interstitial pneumonia [J].
Atkins, SR ;
Turesson, C ;
Myers, JL ;
Tazelaar, HD ;
Ryu, JH ;
Matteson, EL ;
Bongartz, T .
ARTHRITIS AND RHEUMATISM, 2006, 54 (02) :635-641
[6]   Pulmonary involvement in rheumatoid arthritis [J].
Bilgici, A ;
Ulusoy, H ;
Kuru, O ;
Çelenk, Ç ;
Ünsal, M ;
Danaci, M .
RHEUMATOLOGY INTERNATIONAL, 2005, 25 (06) :429-435
[7]   Ectopic lymphoid tissues and local immunity [J].
Carragher, Damian M. ;
Rangel-Moreno, Javier ;
Randall, Troy D. .
SEMINARS IN IMMUNOLOGY, 2008, 20 (01) :26-42
[8]   Comparison of Threshold Cutpoints and Continuous Measures of Anti-Cyclic Citrullinated Peptide Antibodies in Predicting Future Rheumatoid Arthritis [J].
Chibnik, Lori B. ;
Mandl, Lisa A. ;
Costenbader, Karen H. ;
Schur, Peter H. ;
Karlson, Elizabeth W. .
JOURNAL OF RHEUMATOLOGY, 2009, 36 (04) :706-711
[9]   RHEUMATOID-FACTOR ACCENTUATION OF PULMONARY LESIONS ASSOCIATED WITH EXPERIMENTAL DIFFUSE PROLIFERATIVE LUNG-DISEASE [J].
DEHORATIUS, RJ ;
WILLIAMS, RC .
ARTHRITIS AND RHEUMATISM, 1972, 15 (03) :293-+
[10]   Airways abnormalities and rheumatoid arthritis-related autoantibodies in subjects without arthritis: Early injury or initiating site of autoimmunity? [J].
Demoruelle, M. Kristen ;
Weisman, Michael H. ;
Simonian, Philip L. ;
Lynch, David A. ;
Sachs, Peter B. ;
Pedraza, Isabel F. ;
Harrington, Annie R. ;
Kolfenbach, Jason R. ;
Striebich, Christopher C. ;
Pham, Quyen N. ;
Strickland, Colin D. ;
Petersen, Brian D. ;
Parish, Mark C. ;
Derber, Lezlie A. ;
Norris, Jill M. ;
Holers, V. Michael ;
Deane, Kevin D. .
ARTHRITIS AND RHEUMATISM, 2012, 64 (06) :1756-1761