Function and biogenesis of iron-sulphur proteins

被引：887
作者：
Lill, Roland [1 ]
机构：
[1] Univ Marburg, Inst Zytobiol, D-35033 Marburg, Germany
来源：
NATURE | 2009年 / 460卷 / 7257期
关键词：
FE-S CLUSTER; CYSTEINE DESULFURASE ACTIVITY; ESCHERICHIA-COLI; SCAFFOLD PROTEIN; CRYSTAL-STRUCTURE; ASSEMBLY PROTEIN; 2FE-2S CLUSTER; MITOCHONDRIAL; ISCU; TRANSPORTER;
D O I：
10.1038/nature08301
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Iron-sulphur (Fe-S) clusters have long been recognized as essential and versatile cofactors of proteins involved in catalysis, electron transport and sensing of ambient conditions. Despite the relative simplicity of Fe-S clusters in terms of structure and composition, their synthesis and assembly into apoproteins is a highly complex and coordinated process in living cells. Different biogenesis machineries in both bacteria and eukaryotes have been discovered that assist Fe-S-protein maturation according to uniform biosynthetic principles. The importance of Fe-S proteins for life is documented by an increasing number of diseases linked to these components and their biogenesis.
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页码：831 / 838
页数：8
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