An E2F-like repressor of transcription

被引：103
作者：
Morkel, M
Wenkel, J
Bannister, AJ
Kouzarides, T
Hagemeier, C
机构：
[1] UNIV CAMBRIDGE,WELLCOME CRC INST,CAMBRIDGE CB2 1QR,ENGLAND
[2] UNIV CAMBRIDGE,DEPT PATHOL,CAMBRIDGE CB2 1QR,ENGLAND
[3] HUMBOLDT UNIV BERLIN,CHARITE VIRCHOW MED CTR,DEPT PAEDIAT,D-13353 BERLIN,GERMANY
来源：
NATURE | 1997年 / 390卷 / 6660期
关键词：
D O I：
10.1038/37507
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The activity of a variety of genes whose products are involved in DNA replication and cell-cycle progression are regulated by E2F transcription factors, which bind to E2F sites on DNA in cooperation with members of the DP family of transcription factors1. E2F sites can act as both positive and negative control elements2. Transcriptional activation from E2F sites is mediated by ‘free’ E2F, whereas repression conventionally requires the formation of a complex with a pocket protein (retinoblastoma protein (RB), p107 or p130)3. Here we describe an E2F-like protein, termed EMA (for E2F-binding site modulating activity), which can act as a repressor of transcription without a pocket protein.
引用
收藏
页码：567 / 568
页数：2
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