Is adrenomedullin a causal agent in some cases of type 2 diabetes?

被引：58

作者：

Martínez, A

Elsasser, TH

Bhathena, SJ

Pío, R

Buchanan, TA

Macri, CJ

Cuttitta, F

机构：

[1] NCI, Dept Cell & Canc Biol, Med Branch, Div Clin Sci,NIH, Bethesda, MD 20892 USA

[2] ARS, USDA, Beltsville, MD 20705 USA

[3] Univ So Calif, Sch Med, Dept Med, Los Angeles, CA 90033 USA

[4] Univ So Calif, Sch Med, Dept Obstet & Gynecol, Los Angeles, CA 90033 USA

[5] Uniformed Serv Univ Hlth Sci, Dept Obstet & Gynecol, Bethesda, MD 20814 USA

来源：

PEPTIDES | 1999年 / 20卷 / 12期

关键词：

adrenomedullin; gastational diabetes; radioimmunoassay; glucose tolerance; glycemia regulation; diabetic rat model;

D O I：

10.1016/S0196-9781(99)00158-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The study of two populations with a recent onset of type 2 diabetes showed that a subset of the patients had higher levels of adrenomedullin (AM) than the rest of the diabetics. In this subset, physiological elevations of AM might have triggered the disease in predisposed individuals. Diabetics showed higher levels of AM than healthy controls. In addition, glycemia was measured in diabetic rats after injection of saline, AM, or antiAM antibody. AM elevated glycemia, whereas the antibody reduced circulating glucose to normal. These results suggest that manipulation of AM levels could represent a new approach in the management of diabetes for the appropriate individuals. Published by Elsevier Science Inc.

引用

页码：1471 / 1478

页数：8

共 49 条

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