Cobalt-Catalyzed Regio- and Enantioselective Allylic Amination

被引：94

作者：

Ghorai, Samir ^{[1
]}

Chirke, Sahadev Shrihari ^{[1
]}

Xu, Wen-Bin ^{[1
]}

Chen, Jia-Feng ^{[1
]}

Li, Changkun ^{[1
,2
]}

机构：

[1] Shanghai Jiao Tong Univ, Sch Chem & Chem Engn, Shanghai Key Lab Mol Engn Chiral Drugs, 800 Dongchuan Rd, Shanghai 200240, Peoples R China

[2] Beijing Natl Lab Mol Sci, Beijing 100871, Peoples R China

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2019年 / 141卷 / 29期

基金：

中国国家自然科学基金;

关键词：

ALLYLATION; LIGANDS; HYDROGENATION; REDUCTION; COMPLEXES; ENANTIO;

D O I：

10.1021/jacs.9b06035

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The first earth-abundant cobalt-catalyzed highly branched- and enantioselective allylic amination of racemic branched allylic carbonates bearing alkyl groups with both aromatic and aliphatic amines has been developed. The process allows rapid access of allylic amines in high yields with exclusively branched selectivity and excellent enantioselectivities (normally 99% ee) under mild reaction conditions.

引用

页码：11430 / 11434

页数：5

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