Carrier-Free, Pure Nanodrug Formed by the Self-Assembly of an Anticancer Drug for Cancer Immune Therapy

被引：107
作者：
Fan, Lulu [1 ,2 ]
Zhang, Bingchen [1 ,2 ]
Xu, Alicia [1 ,2 ]
Shen, Zhichun [1 ,2 ]
Guo, Yan [1 ,2 ]
Zhao, Ruirui [1 ,2 ]
Yao, Huilu [3 ]
Shao, Jing-Wei [1 ,2 ]
机构：
[1] Fuzhou Univ, Canc Metastasis Alert & Prevent Ctr, State Key Lab Photocatalysis Energy & Environm, Pharmaceut Photocatalysis, Fuzhou 350108, Fujian, Peoples R China
[2] Fuzhou Univ, Coll Chem, Fujian Prov Key Lab Canc Metastasis Chemoprevent, Fuzhou 350108, Fujian, Peoples R China
[3] Guangxi Univ, Sch Phys Sci & Technol, Guangxi 530004, Peoples R China
来源：
MOLECULAR PHARMACEUTICS | 2018年 / 15卷 / 06期
基金：
中国国家自然科学基金;
关键词：
carrier-free nanodrug; self-assembly; UA NPs; liver protection; immunotherapy; URSOLIC ACID-DERIVATIVES; IN-VITRO; PHOTODYNAMIC THERAPY; DELIVERY-SYSTEM; LUNG-CANCER; NANOPARTICLES; PHARMACOKINETICS; PATHWAYS; PRODRUG; TUMOR;
D O I：
10.1021/acs.molpharmaceut.8b00444
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Ursolic acid (UA) is a food-plant-derived natural product which has good anticancer activities and low toxicity. However, the poor water solubility of UA limits its application in clinic. To address this issue, we developed a carrier-free nanodrug by self-assembly of UA. Here, we showed that UA nanoparticles (NPs) have a near-spherical shape with a diameter of 450 nm. UA NPs exhibited higher antiproliferative activity; significantly caused apoptosis; decreased the expression of COX-2/VEGFR2/VEGFA; and increased the immunostimulatory activity of TNF-alpha, IL-6, and IFN-beta and decreased the activity of STAT-3 in A549 cells in vitro. Furthermore, UA NPs could inhibit tumor growth and have the ability of liver protection in vivo. More importantly, UA NPs could significantly improve the activation of CD4+ T-cells, which indicated that UA NPs have the potential for immunotherapy. Overall, a carrier-free UA nanodrug may be a promising drug to further enhance their anticancer efficacy and immune function.
引用
收藏
页码：2466 / 2478
页数：13
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