Efficacy of IP-10 as a biomarker for monitoring tuberculosis treatment

被引：42

作者：

Hong, Ji Young ^{[1
]}

Lee, Hye Jon ^{[2
]}

Kim, Song Yee ^{[1
]}

Chung, Kyung Soo ^{[1
]}

Kim, Eun Young ^{[1
]}

Jung, Ji Ye ^{[1
]}

Park, Moo Suk ^{[1
]}

Kim, Young Sam ^{[1
]}

Kim, Se Kyu ^{[1
]}

Chang, Joon ^{[1
]}

Cho, Sang-Nae ^{[2
]}

Kang, Young Ae ^{[1
]}

机构：

[1] Yonsei Univ, Coll Med, Dept Internal Med, Div Pulmonol, Seoul 120752, South Korea

[2] Yonsei Univ, Coll Med, Dept Microbiol, Seoul 120752, South Korea

来源：

JOURNAL OF INFECTION | 2014年 / 68卷 / 03期

关键词：

IP-10; Monitoring; Tuberculosis; T-CELL RESPONSES; INDUCIBLE PROTEIN 10; PULMONARY TUBERCULOSIS; ACTIVE TUBERCULOSIS; ANTITUBERCULOSIS TREATMENT; CULTURE CONVERSION; GAMMA-INTERFERON; DISEASE-ACTIVITY; WHOLE-BLOOD; DIAGNOSIS;

D O I：

10.1016/j.jinf.2013.09.033

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Objectives: IP-10 has been proposed as a promising alternative marker for the diagnosis of tuberculosis (TB). Methods: In this exploratory study, we assessed the levels of serum IP-10 and TB antigen-dependent IP-10 at the time of diagnosis and after completing treatment in 32 patients with active TB. Results: Significant changes in concentration between the time of diagnosis and the completion of therapy were observed for serum IP-10 (P < 0.001; median: 140.4 and 105.7 pg/ml, respectively) and TB antigen-dependent IP-10 (P = 0.002; median: 20,000 and 13,720 pg/ml, respectively). The proportion of TB antigen-dependent IP-10 responders did not change significantly between baseline and the completion of therapy (P = 0.35), whereas the proportion of serum IP-10 responders was significantly different (P = 0.001). Conclusions: Serum IP-10 and TB antigen-dependent IP-10 responses to QFT-GIT antigens might be a useful biomarker for monitoring the efficacy of therapy in patients with active TB. (C) 2013 The British Infection Association. Published by Elsevier Ltd. All rights reserved.

引用

页码：252 / 258

页数：7

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