BASE-MEDIATED BIGINELLI-LIKE REACTION IGNITED BY AROMATIC ISOCYANATE: A FACILE ONE-POT SYNTHESIS OF N4-ARYL-5-CARBOXYL-6-METHYL CYTIMIDINE DERIVATIVES

被引：2

作者：

Liang, Chengyuan ^{[1
]}

Song, Huihui ^{[1
]}

Jiang, Hailong ^{[2
]}

Yao, Qizheng ^{[2
]}

机构：

[1] Shaanxi Univ Sci & Technol, Dept Pharm, Xian 710021, Peoples R China

[2] China Pharmaceut Univ, Sch Pharm, Nanjing, Jiangsu, Peoples R China

来源：

SYNTHETIC COMMUNICATIONS | 2014年 / 44卷 / 20期

关键词：

Biginelli reaction; isocyanate; multicomponent reaction; pyrimidine; 3,4-DIHYDROPYRIMIDIN-2(1H)-ONES; CATALYSIS;

D O I：

10.1080/00397911.2014.908309

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The new three-component Biginelli reaction of aromatic isocyanate, ethyl acetoacetate, and substituted urea (or thiourea as well as guanidine) is described for the first time. In this reaction, N-4 -aryl-5-carboxyl-6-methyl cytimidine derivatives were obtained in moderate to excellent yields by employing DBU as a highly effective catalyst. This methodology provides several advantages such as good functional group tolerance, excellent yields, atom efficiency, and experimental simplicity.

引用

页码：2930 / 2935

页数：6

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