Evaluation of BCRP and MDR-1 co-expression by quantitative molecular assessment in AML patients

被引：35

作者：

Galimberti, S

Guerrini, F

Palumbo, GA

Consoli, U

Fazzi, R

Morabito, F

Santini, V

Petrini, M

机构：

[1] Univ Pisa, Osped S Chiara, Sect Hematol, Dept Oncol Transplant & Adv Med, I-56100 Pisa, Italy

[2] Catania Univ, Hematol Sect, Catania, Italy

[3] AO Reggio Calabria, Bone Marrow Transplant Unit, Reggio Di Calabria, Italy

[4] Univ Florence, Div Hematol, Florence, Italy

来源：

LEUKEMIA RESEARCH | 2004年 / 28卷 / 04期

关键词：

multidrug resistance; AML; BCRP; MDR1; real-time PCR; quantitative PCR;

D O I：

10.1016/j.leukres.2003.09.002

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Expression of two MDR genes, BCRP and MDR1, was evaluated by real-time PCR technique in 51 AML patients. Fifty-six percent expressed the BCRP gene, with the 48.2% showing intermediate levels. Eighty-eight percent expressed the MDR1, with 23.8% of cases at high expression. A significant correlation between BCRP and MDR1 values was found by regression analysis. Either levels of BCRP or MDR1 did not correlate with clinical characteristics of patients at diagnosis. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：367 / 372

页数：6

共 18 条

[1] Low levels of ABCG2 expression in adult AML blast samples [J].