Congenital Chagas disease involves Trypanosoma cruzi sub-lineage IId in the northwestern province of Salta, Argentina

被引：48

作者：

Corrales, Rosa M. ^{[1
]}

Mora, Maria C. ^{[2
]}

Sanchez Negrette, Olga ^{[2
]}

Diosque, Patricio ^{[3
]}

Lacunza, Diego ^{[2
]}

Virreira, Myrna ^{[4
]}

Breniere, Simone F.

Basombrio, Miguel A. ^{[2
]}

机构：

[1] Inst Rech Dev, Dept Soc & Sante, UR Caracterisat & Controle Populat Vecteurs 016, F-34394 Montpellier, France

[2] Univ Nacl Salta, CONICET, INSIBIO, Inst Patol Expt, RA-4400 Salta, Argentina

[3] Univ Nacl Salta, CONICET, Unidad Epidemiol Mol, Inst Patol Expt, RA-4400 Salta, Argentina

[4] Univ Libre Bruxelles, Fac Med, B-1070 Brussels, Belgium

来源：

INFECTION GENETICS AND EVOLUTION | 2009年 / 9卷 / 02期

关键词：

Congenital Chagas disease; Lineages; Trypanosoma cruzi IId; Multilocus enzyme electrophoresis (MLEE); Random amplified polymorphic DNA (RAPD); MULTILOCUS ENZYME ELECTROPHORESIS; PHYLOGENETIC LINEAGES; INFECTION; TRANSMISSION; POPULATIONS; PARASITE; IDENTIFICATION; PREDOMINANCE; EPIDEMIOLOGY; VARIABILITY;

D O I：

10.1016/j.meegid.2008.12.008

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Trypanosoma cruzi is genetically classified into six discrete phylogenetic lineages on the basis of different genetic markers. Identifying lineages circulating among humans in different areas is essential to understand the molecular epidemiology of Chagas disease. In the present study, 18 T. cruzi isolates from congenitally infected newborns in the northwestern province of Salta-Argentina were studied by multilocus enzyme electrophoresis (MLEE) and random amplified polymorphic DNA (RAPD). All isolates were typed by MLEE and RAPID as belonging to T. cruzi lid. Analysis of minor variants of TcIId using probes hybridizing with hypervariable domains of kDNA minicircles, detected three variants with a similar distribution among the isolates. Our findings confirm the presence of T. cruzi IId among congenitally infected newborns in northwestern Argentina and support the assumption that human infection by T. cruzi in the Southern Cone countries of Latin America is due principally to T. cruzi II. (C) 2008 Elsevier B.V. All rights reserved.

引用

页码：278 / 282

页数：5

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