Reprogramming microorganisms for the biosynthesis of astaxanthin via metabolic engineering

被引：53

作者：

Wan, Xia ^{[1
,2
,3
]}

Zhou, Xue-Rong ^{[4
]}

Moncalian, Gabriel ^{[5
,6
]}

Su, Lin ^{[7
]}

Chen, Wen-Chao ^{[1
,2
,3
]}

Zhu, Hang-Zhi ^{[1
]}

Chen, Dan ^{[1
]}

Gong, Yang-Min ^{[1
,2
,3
]}

Huang, Feng-Hong ^{[1
,2
,3
]}

Deng, Qian-Chun ^{[1
,2
,3
]}

机构：

[1] Chinese Acad Agr Sci, Oil Crops Res Inst, Wuhan 430062, Peoples R China

[2] Minist Agr, Key Lab Biol & Genet Improvement Oil Crops, Wuhan 430062, Peoples R China

[3] Oil Crops & Lipids Proc Technol Natl & Local Join, Wuhan 430062, Peoples R China

[4] CSIRO Agr & Food, Canberra, ACT 2601, Australia

[5] Univ Cantabria, Dept Biol Mol, Santander, Spain

[6] Univ Cantabria, Inst Biomed & Biotecnol Cantabria IBBTEC, CSIC, Santander, Spain

[7] Inner Mongolia Agr Univ, Coll Food Sci & Engn, Hohhot 010018, Peoples R China

来源：

PROGRESS IN LIPID RESEARCH | 2021年 / 81卷

关键词：

Astaxanthin; Metabolic engineering; Synthetic biology; Carotenoid; ALGA HAEMATOCOCCUS-PLUVIALIS; BETA-CAROTENE KETOLASE; DIFFERENT STEREOISOMERIC ASTAXANTHIN; ESCHERICHIA-COLI; MEVALONATE PATHWAY; SACCHAROMYCES-CEREVISIAE; CHLORELLA-ZOFINGIENSIS; PHAFFIA-RHODOZYMA; OXIDATIVE STRESS; MARINE BACTERIUM;

D O I：

10.1016/j.plipres.2020.101083

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

There is an increasing demand for astaxanthin in food, feed, cosmetics and pharmaceutical applications because of its superior anti-oxidative and coloring properties. However, naturally produced astaxanthin is expensive, mainly due to low productivity and limited sources. Reprogramming of microorganisms for astaxanthin production via metabolic engineering is a promising strategy. We primarily focus on the application of synthetic biology, enzyme engineering and metabolic engineering in enhancing the synthesis and accumulation of astaxanthin in microorganisms in this review. We also discuss the biosynthetic pathways of astaxanthin within natural producers, and summarize the achievements and challenges in reprogramming microorganisms for enhancing astaxanthin production. This review illuminates recent biotechnological advances in microbial production of astaxanthin. Future perspectives on utilization of new technologies for boosting microbial astaxanthin production are also discussed.

引用

页数：19

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