Serpents on the road to dementia and death

被引：13

作者：

Beyreuther, K ^{[1
]}

Masters, CL ^{[1
]}

机构：

[1] UNIV MELBOURNE, DEPT PATHOL, PARKVILLE, VIC 3025, AUSTRALIA

来源：

NATURE MEDICINE | 1997年 / 3卷 / 07期

关键词：

D O I：

10.1038/nm0797-723

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Accumulating evidence from several studies points to the normal function of presenilin 1 and suggests how the mutant protein contributes to deposition of amyloid plaques in Alzheimer's disease (pages 756–760).

引用

页码：723 / 725

页数：3

共 12 条

[1]

BOTTO M, IN PRESS NATURE MED

[2] RETRACTED: Mutations in mitochondrial cytochrome c oxidase genes segregate with late-onset Alzheimer disease (Retracted Article) [J].

Davis, RE ;

Miller, S ;

Herrnstadt, C ;

Ghosh, SS ;

Fahy, E ;

Shinobu, LA ;

Galasko, D ;

Thal, LJ ;

Beal, MF ;

Howell, N ;

Parker, WD .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (09) :4526-4531

[3] Increased amyloid-beta 42(43) in brains of mice expressing mutant presenilin 1 [J].

Duff, K ;

Eckman, C ;

Zehr, C ;

Yu, X ;

Prada, CM ;

Pereztur, J ;

Hutton, M ;

Buee, L ;

Harigaya, Y ;

Yager, D ;

Morgan, D ;

Gordon, MN ;

Holcomb, L ;

Refolo, L ;

Zenk, B ;

Hardy, J ;

Younkin, S .

NATURE, 1996, 383 (6602) :710-713

[4] Notch3 mutations in CADASIL, a hereditary adult-onset condition causing stroke and dementia [J].

Joutel, A ;

Corpechot, C ;

Ducros, A ;

Vahedi, K ;

Chabriat, H ;

Mouton, P ;

Alamowitch, S ;

Domenga, V ;

Cecillion, M ;

Marechal, E ;

Maciazek, J ;

Vayssiere, C ;

Cruaud, C ;

Cabanis, EA ;

Ruchoux, MM ;

Weissenbach, J ;

Bach, JF ;

Bousser, MG ;

TournierLasserve, E .

NATURE, 1996, 383 (6602) :707-710

[5] Hyperaccumulation of FAD-linked presenilin 1 variants in vivo [J].

Lee, MK ;

Borchelt, DR ;

Kim, G ;

Thinakaran, G ;

Slunt, HH ;

Ratovitski, T ;

Martin, LJ ;

Kittur, A ;

Gandy, S ;

Levey, AI ;

Jenkins, N ;

Copeland, N ;

Price, DL ;

Sisodia, SS .

NATURE MEDICINE, 1997, 3 (07) :756-760

[6] Impaired learning and LTP in mice expressing the carboxy terminus of the Alzheimer amyloid precursor protein [J].

Nalbantoglu, J ;

TiradoSantiago, G ;

Lahsaini, A ;

Poirier, J ;

Goncalves, O ;

Verge, A ;

Momoli, F ;

Welner, SA ;

Massicotte, G ;

Julien, JP ;

Shapiro, ML .

NATURE, 1997, 387 (6632) :500-505

[7]

Sandbrink R, 1996, MOL PSYCHIATR, V1, P27

[8] Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease [J].

Scheuner, D ;

Eckman, C ;

Jensen, M ;

Song, X ;

Citron, M ;

Suzuki, N ;

Bird, TD ;

Hardy, J ;

Hutton, M ;

Kukull, W ;

Larson, E ;

LevyLahad, E ;

Viitanen, M ;

Peskind, E ;

Poorkaj, P ;

Schellenberg, G ;

Tanzi, R ;

Wasco, W ;

Lannfelt, L ;

Selkoe, D ;

Younkin, S .

NATURE MEDICINE, 1996, 2 (08) :864-870

[9] Skeletal and CNS defects in Presenilin-1-deficient mice [J].

Shen, J ;

Bronson, RT ;

Chen, DF ;

Xia, WM ;

Selkoe, DJ ;

Tonegawa, S .

CELL, 1997, 89 (04) :629-639

[10]

Tienari PJ, 1996, COLD SPRING HARB SYM, V61, P575

← 1 2 →