Nuclear phosphoproteins HMGA and their relationship with chromatin structure and cancer

被引：198

作者：

Sgarra, R

Rustighi, A

Tessari, MA

Di Bernardo, J

Altamura, S

Fusco, A

Manfioletti, G

Giancotti, V

机构：

[1] Univ Trieste, Dipartimento Biochim Biofis & Chim Macromol, I-34127 Trieste, Italy

[2] Univ Udine, Dipartimento Patol & Med Sperimentale & Clin, I-33100 Udine, Italy

[3] Univ Naples Federico II, CNR, Ctr Endocrinol & Oncol Sperimentale, Dipartimento Biol & Patol Cellulare & Mol, I-80131 Naples, Italy

来源：

FEBS LETTERS | 2004年 / 574卷 / 1-3期

关键词：

high mobility group A proteins; methylation; phosphorylation; post-translational modification; chromatin; epigenetic process; cancer;

D O I：

10.1016/j.febslet.2004.08.013

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The structural characteristics of the three nuclear phosphoproteins of the high mobility group A family are outlined and related to their participation in chromatin structure alteration in many biological processes such as gene expression, neoplastic transformation, differentiation, and apoptosis. The elevated expression of these proteins in tumor cells and their post-translational modifications, such as phosphorylation, acetylation and methylation, are discussed and suggested as suitable targets for cancer chemotherapy. (C) 2004 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：1 / 8

页数：8

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