Role of the mitochondrial contact site and cristae organizing system in membrane architecture and dynamics

被引：124
作者：
Rampelt, Heike [1 ]
Zerbes, Ralf M. [1 ,2 ]
van der Laan, Martin [3 ]
Pfanner, Nikolaus [1 ,4 ]
机构：
[1] Univ Freiburg, Inst Biochem & Mol Biol, ZBMZ, Fac Med, D-79104 Freiburg, Germany
[2] Univ Freiburg, Fac Biol, D-79104 Freiburg, Germany
[3] Univ Saarland, Med Biochem & Mol Biol, D-66421 Homburg, Germany
[4] Univ Freiburg, BIOSS Ctr Biol Signalling Studies, D-79104 Freiburg, Germany
来源：
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH | 2017年 / 1864卷 / 04期
关键词：
Crista junction; Cristae; MICOS; Mitochondria; Phospholipid; RESPIRATORY-CHAIN SUPERCOMPLEXES; AMYOTROPHIC-LATERAL-SCLEROSIS; INNER-MEMBRANE; INTERMEMBRANE SPACE; ATP SYNTHASE; SACCHAROMYCES-CEREVISIAE; OUTER-MEMBRANE; PROTEIN IMPORT; BARTH-SYNDROME; COILED-COIL;
D O I：
10.1016/j.bbamcr.2016.05.020
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The elaborate membrane architecture of mitochondria is a prerequisite for efficient respiration and ATP generation. The cristae membranes, invaginations of the inner mitochondrial membrane, represent a specialized compartment that harbors the complexes of the respiratory chain and the FiFo-ATP synthase. Crista junctions form narrow openings that connect the cristae membranes to the inner boundary membrane. The mitochondrial contact site and cristae organizing system (MICOS) is located at crista junctions where it stabilizes membrane curvature and forms contact sites between the mitochondrial inner and outer membranes. MICOS is a large machinery, consisting of two dynamic subcomplexes that are anchored in the inner membrane and expose domains to the intermembrane space. The functions of MICOS in mitochondrial membrane architecture and biogenesis are influenced by numerous interaction partners and the phospholipid environment. (C) 2016 Elsevier B.V. All rights reserved.
引用
收藏
页码：737 / 746
页数：10
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