Strong association between HLA-Cw*0706 and HLA-B*44032 in the Bubi population from Equatorial Guinea

被引：8
作者：
van der Vlies, SA
Voorter, CEM
de Pablo, R
Vilches, C
van den Berg-Loonen, EM
机构：
[1] Univ Hosp Maastricht, Tissue Typing Lab, NL-6202 AZ Maastricht, Netherlands
[2] HU Clin Puerta de Hierro, Serv Immunol, Madrid, Spain
来源：
TISSUE ANTIGENS | 2000年 / 55卷 / 01期
关键词：
HLA-class I; HLA-B; HLA-C; sequence-based typing; DNA-typing; histocompatibility testing; Bubi;
D O I：
10.1034/j.1399-0039.2000.550110.x
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Unrelated Bubi, native to the island of Bioko (Equatorial Guinea), were previously typed by low-resolution polymerase chain reaction using sequence-specific primers (PCR-SSP) and serology for HLA-A, -B and -C, HLA-B*44 was found frequently and associated with Cw*07. We have studied the HLA subtypes of 20 B*44pos/Cw*07pos Bubi individuals. HLA-B and -C were typed by sequencing exons 2 and 3, To distinguish the alleles Cw*1701/02/03, Cw*07011/012/06 and Cw*1801/02 additional sequencing of exon 1 or 5 was performed. All B*44pos/Cw*07pos individuals of the Bubi population were typed Cw*0706 positive. Nineteen of them carried the B*44032 allele and one B*4407. In addition, 19 B*44neg/ Cw*07pos Bubi individuals were typed for HLA-C and none of them proved Cw*0706 positive. To determine whether the association between Cw*0706 and B*44032 was limited to the Bubi, 19 individuals from Dutch Caucasian families were typed in which B44 and Cw7 segregated on one haplotype. None of these individuals showed the presence of B*44032 or Cw*0706. The haplotypes found in the Dutch Caucasians were B*4402-Cw*0704, B*44031-Cw*07011 and B*44031-Cw*0702. The present observation indicates a strong association between B*44032 and Cw*0706 in the Bubi population.
引用
收藏
页码：57 / 60
页数：4
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