Detecting the effect of very low amounts of penetrants in lipid bilayers using Raman spectroscopy

被引：7
|
作者：
Meier, Robert J. [1 ]
Csiszar, Agnes
Klumpp, Erwin
机构：
[1] Res Ctr Julich, Inst Agrosphere, D-52428 Julich, Germany
[2] DSM Res & Patents, NL-6160 MD Geleen, Netherlands
来源：
JOURNAL OF PHYSICAL CHEMISTRY B | 2006年 / 110卷 / 42期
关键词：
D O I：
10.1021/jp0615757
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
We show that, by the influence on the gauche content in the acyl chains, the effect of very low concentrations (order 10-2 %) of penetrants (here 2,4- dichlorophenol) in lipid bilayers (here dipalmitoyl- glycerophosphatidylcholine) can be experimentally seen in the Raman spectra. The observed effects suggest increased order and are in accordance with previous X-ray diffraction and calorimetric data. These findings show great promise for studying in situ the effect of low amounts of various small molecules on cell membranes using Raman spectroscopy.
引用
收藏
页码：20727 / 20728
页数：2
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