Synaptic vesicle biogenesis

被引：145
作者：
Hannah, MJ
Schmidt, AA
Huttner, WB
机构：
[1] UCL, MRC, Mol Cell Biol Lab, London WC1E 6BT, England
[2] Heidelberg Univ, Dept Neurobiol, D-69120 Heidelberg, Germany
[3] Max Planck Inst Mol Cell Biol & Genet, D-01307 Dresden, Germany
来源：
ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY | 1999年 / 15卷
关键词：
membrane budding; membrane fission; membrane traffic; sorting synaptic-like microvesicles;
D O I：
10.1146/annurev.cellbio.15.1.733
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Synaptic vesicles, which have been a paradigm for the fusion of a vesicle with its target membrane, also serve as a model for understanding the formation of a vesicle from its donor membrane. Synaptic vesicles, which are formed and recycled at the periphery of the neuron, contain a highly restricted set of neuronal proteins. Insight into the trafficking of synaptic vesicle proteins has come from studying not only neurons but also neuroendocrine cells, which form synaptic-like microvesicles (SLMVs). Formation and recycling of synaptic vesicles/SLMVs takes place from the early endosome and the plasma membrane. The cytoplasmic machinery of synaptic vesicle/SLMV formation and recycling has been studied by a variety of experimental approaches, in particular using cell-free systems. This has revealed distinct machineries for membrane budding and fission. Budding is mediated by clathrin and clathrin adaptors, whereas fission is mediated by dynamin and its interacting protein SH3p4, a lysophosphatidic acid acyl transferase.
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收藏
页码：733 / 798
页数：66
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