May the force be with you: Myosin-X in phagocytosis.

被引：9
作者：
Chavrier, P [1 ]
机构：
[1] Inst Curie, Sect Rech, F-75005 Paris, France
来源：
NATURE CELL BIOLOGY | 2002年 / 4卷 / 07期
关键词：
D O I：
10.1038/ncb0702-e169
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Engulfment of pathogens by phagocytosis requires the coordination of actin assembly and progressive 'zippering' of pseudopodial membranes around the particle. Recent work shows that Myosin-X, which binds phosphatidylinositol-3-OH kinase (PI(3) K) products through its pleckstrin homology (PH) domains, is required for phagocytosis, thereby providing a molecular basis for the function of PI(3) K in pseudopod extension.
引用
收藏
页码：E169 / E171
页数：3
相关论文
共 22 条
  • [1] Mechanisms of phagocytosis in macrophages
    Aderem, A
    Underhill, DM
    [J]. ANNUAL REVIEW OF IMMUNOLOGY, 1999, 17 : 593 - 623
  • [2] A ROLE FOR MARCKS, THE ALPHA-ISOZYME OF PROTEIN-KINASE-C AND MYOSIN-I IN ZYMOSAN PHAGOCYTOSIS BY MACROPHAGES
    ALLEN, LAH
    ADEREM, A
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1995, 182 (03) : 829 - 840
  • [3] A role for phosphoinositide 3-kinase in the completion of macropinocytosis and phagocytosis by macrophages
    Araki, N
    Johnson, MT
    Swanson, JA
    [J]. JOURNAL OF CELL BIOLOGY, 1996, 135 (05) : 1249 - 1260
  • [4] Focal exocytosis of VAMP3-containing vesicles at sites of phagosome formation
    Bajno, L
    Peng, XR
    Schreiber, AD
    Moore, HP
    Trimble, WS
    Grinstein, S
    [J]. JOURNAL OF CELL BIOLOGY, 2000, 149 (03) : 697 - 705
  • [5] Berg JS, 2000, J CELL SCI, V113, P3439
  • [6] A millennial myosin census
    Berg, JS
    Powell, BC
    Cheney, RE
    [J]. MOLECULAR BIOLOGY OF THE CELL, 2001, 12 (04) : 780 - 794
  • [7] Myosin-X is an unconventional myosin that undergoes intrafilopodial motility
    Berg, JS
    Cheney, RE
    [J]. NATURE CELL BIOLOGY, 2002, 4 (03) : 246 - 250
  • [8] Membrane dynamics in phagocytosis
    Booth, JW
    Trimble, WS
    Grinstein, S
    [J]. SEMINARS IN IMMUNOLOGY, 2001, 13 (06) : 357 - 364
  • [9] Getting membrane flow and the cytoskeleton to cooperate in moving cells
    Bretscher, MS
    [J]. CELL, 1996, 87 (04) : 601 - 606
  • [10] Actin dynamics during phagocytosis
    Castellano, F
    Chavrier, P
    Caron, E
    [J]. SEMINARS IN IMMUNOLOGY, 2001, 13 (06) : 347 - 355
123