Transition-Metal-Free Arylation of N-Alkyl-tetrahydroisoquinolines under Oxidative Conditions: A Convenient Synthesis of C1-Arylated Tetrahydroisoquinoline Alkaloids

被引：27

作者：

Singh, Kamal Nain ^{[1
,2
]}

Kessar, Satinder V. ^{[1
,2
]}

Singh, Paramjit ^{[1
,2
]}

Singh, Pushpinder ^{[3
]}

Kaur, Manjot ^{[1
,2
]}

Batra, Aanchal ^{[1
,2
]}

机构：

[1] Panjab Univ, Dept Chem, Chandigarh 160014, India

[2] Panjab Univ, Ctr Adv Studies Chem, Chandigarh 160014, India

[3] DAV Univ, Dept Chem, Jalandhar 144025, India

来源：

SYNTHESIS-STUTTGART | 2014年 / 46卷 / 19期

关键词：

arylation; tetrahydroisoquinoline; C-H activation; alkaloids; metal-free; SP(3) C-H; DEHYDROGENATIVE COUPLING REACTIONS; ONE-POT SYNTHESIS; TERTIARY-AMINES; HIGHLY EFFICIENT; BOND ARYLATION; 1-ARYL-TETRAHYDROISOQUINOLINE ANALOGS; DIRECT FUNCTIONALIZATION; NUCLEOPHILIC-ADDITION; CRYPTOSTYLINE-II;

D O I：

10.1055/s-0034-1378337

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A simple protocol for the C1 arylation of tetrahydroisoquinolines with aryl Grignard reagents via diethyl azodicarboxylate (DEAD) mediated oxidative C-H activation under metal-free conditions has been developed. The target compounds, including some naturally occurring alkaloids, were obtained in moderate to good yields.

引用

页码：2644 / 2650

页数：7

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