The role of kallikrein-related peptidases in prostate cancer: potential involvement in an epithelial to mesenchymal transition

被引：28
作者：
Whitbread, Astrid K.
Veveris-Lowe, Tara L.
Lawrence, Mitchell G.
Nicol, David L.
Clements, Judith A. [1 ]
机构：
[1] Queensland Univ Technol, Sch Life Sci, Hormone Dependent Canc Program, Brisbane, Qld 4000, Australia
[2] Queensland Univ Technol, Inst Hlth & Biomed Innovat, Brisbane, Qld 4000, Australia
[3] Princess Alexandra Hosp, Dept Urol, Brisbane, Qld 4102, Australia
来源：
BIOLOGICAL CHEMISTRY | 2006年 / 387卷 / 06期
关键词：
E-cadherin; EMT; KLK4; migration; prostate cancer; PSA;
D O I：
10.1515/BC.2006.089
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Several members of the kallikrein-related peptidase family of serine proteases have proteolytic activities that may affect cancer progression; however, the in vivo significance of these activities remains uncertain. We have demonstrated that expression of PSA or KLK4, but not KLK2, in PC-3 prostate cancer cells changed the cellular morphology from epithelial to spindle-shaped, markedly reduced E-cadherin expression, increased vimentin expression and increased cellular migration. These changes are indicative of an epithelial to mesenchymal transition (EMT), a process important in embryonic development and cancer progression. The potential novel role of kallikrein-related peptidases in this process is the focus of this brief review.
引用
收藏
页码：707 / 714
页数：8
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