The role of kallikrein-related peptidases in prostate cancer: potential involvement in an epithelial to mesenchymal transition

被引：28
作者：
Whitbread, Astrid K.
Veveris-Lowe, Tara L.
Lawrence, Mitchell G.
Nicol, David L.
Clements, Judith A. [1 ]
机构：
[1] Queensland Univ Technol, Sch Life Sci, Hormone Dependent Canc Program, Brisbane, Qld 4000, Australia
[2] Queensland Univ Technol, Inst Hlth & Biomed Innovat, Brisbane, Qld 4000, Australia
[3] Princess Alexandra Hosp, Dept Urol, Brisbane, Qld 4102, Australia
来源：
BIOLOGICAL CHEMISTRY | 2006年 / 387卷 / 06期
关键词：
E-cadherin; EMT; KLK4; migration; prostate cancer; PSA;
D O I：
10.1515/BC.2006.089
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Several members of the kallikrein-related peptidase family of serine proteases have proteolytic activities that may affect cancer progression; however, the in vivo significance of these activities remains uncertain. We have demonstrated that expression of PSA or KLK4, but not KLK2, in PC-3 prostate cancer cells changed the cellular morphology from epithelial to spindle-shaped, markedly reduced E-cadherin expression, increased vimentin expression and increased cellular migration. These changes are indicative of an epithelial to mesenchymal transition (EMT), a process important in embryonic development and cancer progression. The potential novel role of kallikrein-related peptidases in this process is the focus of this brief review.
引用
收藏
页码：707 / 714
页数：8
相关论文
共 108 条
  • [1] Epithelial mesenchymal interactions in cancer and development
    Arias, AM
    [J]. CELL, 2001, 105 (04) : 425 - 431
  • [2] Australian Institute of Health and Welfare (AIHW), 2004, AUSTR HLTH 2004
  • [3] Glycogen synthase kinase-3 is an endogenous inhibitor of snail transcription: implications for the epithelial-mesenchymal transition
    Bachelder, RE
    Yoon, SO
    Franci, C
    de Herreros, AG
    Mercurio, AM
    [J]. JOURNAL OF CELL BIOLOGY, 2005, 168 (01) : 29 - 33
  • [4] Transcriptional activation of integrin β6 during the epithelial-mesenchymal transition defines a novel prognostic indicator of aggressive colon carcinoma
    Bates, RC
    Bellovin, DI
    Brown, C
    Maynard, E
    Wu, BY
    Kawakatsu, H
    Sheppard, D
    Oettgen, P
    Mercurio, AM
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 2005, 115 (02) : 339 - 347
  • [5] The transcription factor Snail is a repressor of E-cadherin gene expression in epithelial tumour cells
    Batlle, E
    Sancho, E
    Franci, C
    Domínguez, D
    Monfar, M
    Baulida, J
    de Herreros, AG
    [J]. NATURE CELL BIOLOGY, 2000, 2 (02) : 84 - 89
  • [6] Crystal structure and biochemical characterization of human kallikrein 6 reveals that a trypsin-like kallikrein is expressed in the central nervous system
    Bernett, MJ
    Blaber, SI
    Scarisbrick, IA
    Dhanarajana, P
    Thomspon, SM
    Blaber, M
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (27) : 24562 - 24570
  • [7] CADHERIN EXPRESSION IN CARCINOMAS - ROLE IN THE FORMATION OF CELL-JUNCTIONS AND THE PREVENTION OF INVASIVENESS
    BIRCHMEIER, W
    BEHRENS, J
    [J]. BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER, 1994, 1198 (01): : 11 - 26
  • [8] The transcription factor Slug represses E-cadherin expression and induces epithelial to mesenchymal transitions:: a comparison with Snail and E47 repressors
    Bolós, V
    Peinado, H
    Pérez-Moreno, MA
    Fraga, MF
    Esteller, M
    Cano, A
    [J]. JOURNAL OF CELL SCIENCE, 2003, 116 (03) : 499 - 511
  • [9] The emerging roles of human tissue kallikreins in cancer
    Borgoño, CA
    Diamandis, EP
    [J]. NATURE REVIEWS CANCER, 2004, 4 (11) : 876 - 890
  • [10] Borgoño CA, 2003, CANCER RES, V63, P9032
12345678910