Rocaglamide, silvestrol and structurally related bioactive compounds from Aglaia species

被引：105

作者：

Pan, Li ^{[1
]}

Woodard, John L. ^{[1
]}

Lucas, David M. ^{[1
,2
]}

Fuchs, James R. ^{[1
]}

Kinghorn, A. Douglas ^{[1
]}

机构：

[1] Ohio State Univ, Coll Pharm, Div Med Chem & Pharmacognosy, Columbus, OH 43210 USA

[2] Ohio State Univ, Coll Med, Div Hematol, Columbus, OH 43210 USA

来源：

NATURAL PRODUCT REPORTS | 2014年 / 31卷 / 07期

基金：

美国国家卫生研究院;

关键词：

TRANSLATION INITIATION; LEUKEMIA-CELLS; IN-VITRO; ENANTIOSELECTIVE PHOTOCYCLOADDITION; CYTOTOXIC CONSTITUENTS; INHIBITOR SILVESTROL; NAZAROV CYCLIZATION; T-CELLS; DERIVATIVES; FLAVAGLINES;

D O I：

10.1039/c4np00006d

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Investigations on the chemistry and biology of rocaglamide, silvestrol and structurally related bioactive compounds from Aglaia species during the period 2006-2013 are reviewed. Included are new phytochemical studies of naturally occurring rocaglamide derivatives, an update on synthetic methods for cyclopenta[b] benzofurans, and a description of the recent biological evaluation and mechanism-of-action studies on compounds of this type.

引用

页码：924 / 939

页数：16

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