Rocaglamide, silvestrol and structurally related bioactive compounds from Aglaia species

被引：105

作者：

Pan, Li ^{[1
]}

Woodard, John L. ^{[1
]}

Lucas, David M. ^{[1
,2
]}

Fuchs, James R. ^{[1
]}

Kinghorn, A. Douglas ^{[1
]}

机构：

[1] Ohio State Univ, Coll Pharm, Div Med Chem & Pharmacognosy, Columbus, OH 43210 USA

[2] Ohio State Univ, Coll Med, Div Hematol, Columbus, OH 43210 USA

来源：

NATURAL PRODUCT REPORTS | 2014年 / 31卷 / 07期

基金：

美国国家卫生研究院;

关键词：

TRANSLATION INITIATION; LEUKEMIA-CELLS; IN-VITRO; ENANTIOSELECTIVE PHOTOCYCLOADDITION; CYTOTOXIC CONSTITUENTS; INHIBITOR SILVESTROL; NAZAROV CYCLIZATION; T-CELLS; DERIVATIVES; FLAVAGLINES;

D O I：

10.1039/c4np00006d

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Investigations on the chemistry and biology of rocaglamide, silvestrol and structurally related bioactive compounds from Aglaia species during the period 2006-2013 are reviewed. Included are new phytochemical studies of naturally occurring rocaglamide derivatives, an update on synthetic methods for cyclopenta[b] benzofurans, and a description of the recent biological evaluation and mechanism-of-action studies on compounds of this type.

引用

页码：924 / 939

页数：16

共 94 条

[1] Constituents of Amoora cucullata with TRAIL resistance-overcoming activity [J].

Ahmed, Firoj ;

Toume, Kazufumi ;

Sadhu, Samir K. ;

Ohtsuki, Takashi ;

Arai, Midori A. ;

Ishibashi, Masami .

ORGANIC & BIOMOLECULAR CHEMISTRY, 2010, 8 (16) :3696-3703

[2] Silvestrol exhibits significant in vivo and in vitro antileukemic activities and inhibits FLT3 and miR-155 expressions in acute myeloid leukemia [J].

Alachkar, Houda ;

Santhanam, Ramasamy ;

Harb, Jason G. ;

Lucas, David M. ;

Oaks, Joshua J. ;

Hickey, Christopher J. ;

Pan, Li ;

Kinghorn, A. Douglas ;

Caligiuri, Michael A. ;

Perrotti, Danilo ;

Byrd, John C. ;

Garzon, Ramiro ;

Grever, Michael R. ;

Marcucci, Guido .

JOURNAL OF HEMATOLOGY & ONCOLOGY, 2013, 6

[3] Dual Targeting of the Cyclin/Rb/E2F and Mitochondrial Pathways in Mantle Cell Lymphoma with the Translation Inhibitor Silvestrol [J].

Alinari, Lapo ;

Prince, Courtney J. ;

Edwards, Ryan B. ;

Towns, William H. ;

Mani, Rajeswaran ;

Lehman, Amy ;

Zhang, Xiaoli ;

Jarjoura, David ;

Pan, Li ;

Kinghorn, A. Douglas ;

Grever, Michael R. ;

Baiocchi, Robert A. ;

Lucas, David M. .

CLINICAL CANCER RESEARCH, 2012, 18 (17) :4600-4611

[4] Thapsakins:: possible biogenetic intermediates towards insecticidal cyclopenta[b]benzofurans from Aglaia edulis [J].

Bacher, M ;

Hofer, O ;

Brader, G ;

Vajrodaya, S ;

Greger, H .

PHYTOCHEMISTRY, 1999, 52 (02) :253-263

[5] DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis [J].

Bartkova, J ;

Horejsi, Z ;

Koed, K ;

Krämer, A ;

Tort, F ;

Zieger, K ;

Guldberg, P ;

Sehested, M ;

Nesland, JM ;

Lukas, C ;

Orntoft, T ;

Lukas, J ;

Bartek, J .

NATURE, 2005, 434 (7035) :864-870

[6] Rocaglamide derivatives are potent inhibitors of NF-κB activation in T-cells [J].

Baumann, B ;

Bohnenstengel, F ;

Siegmund, D ;

Wajant, H ;

Weber, C ;

Herr, I ;

Debatin, KM ;

Proksch, P ;

Wirth, T .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (47) :44791-44800

[7] Flavaglines Alleviate Doxorubicin Cardiotoxicity: Implication of Hsp27 [J].

Bernard, Yohann ;

Ribeiro, Nigel ;

Thuaud, Frederic ;

Tuerkeri, Guelen ;

Dirr, Ronan ;

Boulberdaa, Mounia ;

Nebigil, Canan G. ;

Desaubry, Laurent .

PLOS ONE, 2011, 6 (10)

[8] The biological and therapeutic relevance of mRNA translation in cancer [J].

Blagden, Sarah P. ;

Willis, Anne E. .

NATURE REVIEWS CLINICAL ONCOLOGY, 2011, 8 (05) :280-291

[9] Rocaglamide breaks TRAIL resistance in HTLV-1-associated adult T-cell leukemia/lymphoma by translational suppression of c-FLIP expression [J].

Bleumink, M. ;

Koehler, R. ;

Giaisi, M. ;

Proksch, P. ;

Krammer, P. H. ;

Li-Weber, M. .

CELL DEATH AND DIFFERENTIATION, 2011, 18 (02) :362-370

[10]

Bohnenstengel FI, 1999, Z NATURFORSCH C, V54, P1075

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